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Book

Hand, Foot, and Mouth Disease

Amanda M. Guerra, Emily Orille  1 , Muhammad Waseem  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Hand, Foot, and Mouth Disease

Amanda M. Guerra et al.
Free Books & Documents

Excerpt

Hand, foot, and mouth disease (HFMD) is a common viral illness that usually affects infants and children but can also affect adults. The infection usually involves the hands, feet, mouth, and sometimes, even the genitals and buttocks. The cause of HFMD is coxsackievirus A type 16 in most cases, but many other strains of coxsackievirus can also cause the infection. See Image. Hand, Foot, and Mouth Disease. In the western Pacific, HFMD has been linked to enterovirus. The coxsackievirus is a member of the Picornaviridae family, which includes non-enveloped single-stranded RNA viruses.

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Conflict of interest statement

Disclosure: Amanda Guerra declares no relevant financial relationships with ineligible companies.

Disclosure: Emily Orille declares no relevant financial relationships with ineligible companies.

Disclosure: Muhammad Waseem declares no relevant financial relationships with ineligible companies.

References

    1. Woodland DL. Hand, Foot, and Mouth Disease. Viral Immunol. 2019 May;32(4):159. - PubMed
    1. Zhu L, Yin H, Sun H, Qian T, Zhu J, Qi G, Wang Y, Qi B. The clinical value of aquaporin-4 in children with hand, foot, and mouth disease and the effect of magnesium sulfate on its expression: a prospective randomized clinical trial. Eur J Clin Microbiol Infect Dis. 2019 Jul;38(7):1343-1349. - PubMed
    1. Wu CY, Lin FL. Hand-foot-and-mouth-disease-induced Koebner phenomenon in psoriasis. J Dtsch Dermatol Ges. 2019 May;17(5):549-551. - PubMed
    1. Muzumdar S, Rothe MJ, Grant-Kels JM. The rash with maculopapules and fever in children. Clin Dermatol. 2019 Mar-Apr;37(2):119-128. - PubMed
    1. Nelson BR, Edinur HA, Abdullah MT. Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017. Data Brief. 2019 Jun;24:103868. - PMC - PubMed

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