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. 2017 Jun 28;139(25):8448-8451.
doi: 10.1021/jacs.7b05273. Epub 2017 Jun 15.

Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents

Manuel Guisán-Ceinos  1 , Victor Martín-Heras  1 , Mariola Tortosa  1   2
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Free article

Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents

Manuel Guisán-Ceinos et al. J Am Chem Soc. .
Free article

Abstract

We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents. The reaction is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance. Conveniently, a stable, inexpensive, and commercially available copper salt is used and no added ligand is required.

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