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. 2017 May 30:11:1031-1038.
doi: 10.2147/OPTH.S133060. eCollection 2017.

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion

Shima Fukuoka  1   2   3 , Reiko Arita  2   3   4 , Rika Shirakawa  2   3 , Naoyuki Morishige  2   5
Affiliations

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion

Shima Fukuoka et al. Clin Ophthalmol. .

Abstract

Purpose: To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision.

Methods: Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W. The tear film breakup time (BUT) was measured.

Results: Both KR-1W and BG-4M visualized meibomian gland as clear similar images. The tear film BUT (mean ± SD, 5.6±3.0 vs 9.4±2.3 seconds, P=0.025), the total meiboscore (median [interquartile range], 2 (2-3) vs 0 (0-1), P=0.007) as well as the meibomian gland dropout rate (86% vs 14%, P=0.008) and shortening rate (100% vs 29%, P=0.031) differed significantly between the patient and control groups. The first total ocular HOAs (0.142±0.063 vs 0.130±0.015, P=0.80) were similar in both groups, whereas the stability index of the total HOAs over time (0.0041±0.0048 vs -0.0012±0.0020, P=0.030) differed significantly between the patient and control groups.

Conclusions: Chalazion and its excision were associated with dropout and shortening rate of meibomian glands. The morphological changes of meibomian glands in chalazion may be associated to instability of the tear film, which was suggested by the tear film BUT and the stability of ocular HOAs.

Keywords: chalazion excision; higher-order aberrations; meibography; meibomian gland; wavefront analyzer.

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Conflict of interest statement

Disclosure Dr Arita holds a patent on the noncontact meibography system used in the study (JP Patent Registration No 5281846, US Patent Publication No 2011-0273550A1, EP Patent Publication No 2189108A1). Drs Fukuoka, Shirakawa, and Morishige report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Representative images of an eye with a history of chalazion. Notes: Images of meibomian gland structures in the upper (A, B) and lower (C, D) right eyelids of a 29-year-old man with a history of chalazion in the upper right eyelid were obtained with the noncontact meibography system attached to a slit-lamp (BG-4M) (A, C) and with the wavefront analyzer (KR-1W) equipped with the newly developed meibography program (B, D). Meibomian gland dropout was apparent in the upper eyelid, and meibomian gland shortening was detected in both the upper and lower eyelids. The quality of the images obtained with the two systems was similar.
Figure 2
Figure 2
Sequential wavefront color-coded maps of total ocular HOAs in a control subject and a representative patient with a history of chalazion. Notes: (A) A 43-year-old male control subject. The first total ocular HOA was 0.120. (B) A 41-year-old man with history of chalazia three times in the left eye. The first total ocular HOA was 0.155. The maps are shown for 1-second intervals together with changes in the simulated retinal images of a Landolt ring (optotype with logMAR value of +0.7). Abbreviation: HOA, higher-order aberrations.
Figure 3
Figure 3
Sequential changes in total HOAs over 10 seconds after blinking and the corresponding linear regression curves for a control subject and a representative patient with a history of chalazion. Notes: Spearman’s correlation coefficient (ρ) and corresponding P-values are shown. (A) A 43-year-old control male subject. The SI of the total HOAs over time was 0.0007. (B) A 41-year-old man with history of chalazia three times in the left eye. The SI of the total HOAs over time was 0.0109. Abbreviations: HOAs, higher-order aberrations; SI, stability index.
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