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Review
. 2017 May 30:22:61.
doi: 10.4103/jrms.JRMS_1005_16. eCollection 2017.

Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Jiaming Cui  1   2   3   4 , Wei Lu  2   3   4 , Yong He  2 , Luoyong Jiang  2 , Kuokuo Li  2 , Weimin Zhu  1   2   3   4 , Daping Wang  1   2   3   4
Affiliations
Review

Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Jiaming Cui et al. J Res Med Sci. .

Abstract

Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of literature on the molecular biology of frozen shoulder, and the molecular biological mechanism for periarthritis-induced limitation of shoulder joint movements remains unclear. Research in this field is focused on inflammation and cytokines associated with fibrosis. Repeated investigations confirmed alterations of specified inflammatory mediators and fibrosis-associated cytokines, which might be involved in the pathogenesis of frozen shoulder by causing structural changes of the shoulder joint and eventually the limitation of shoulder movements. The aim of this article is to review studies on molecular biology of frozen shoulder and provide a reference for subsequent research, treatment, and development of new drugs.

Keywords: Cytokines; frozen shoulder; limitation of movements; molecular biology.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Cytokines and proteins related to the stiffness and pain in frozen shoulder. The orange color indicates that the expression is elevated, and the green color indicates decreased
See this image and copyright information in PMC

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