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Editorial
. 2017 May;9(5):E447-E450.
doi: 10.21037/jtd.2017.04.43.

What is the optimal first-line treatment for advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer?

Affiliations
Editorial

What is the optimal first-line treatment for advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer?

Ikuo Sekine. J Thorac Dis. 2017 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest: Honoraria—Chugai Pharmaceutical Co., Novartis Pharma, and Pfizer.

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References

    1. Kris MG, Johnson BE, Berry LD, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 2014;311:1998-2006. 10.1001/jama.2014.3741 - DOI - PMC - PubMed
    1. Gainor JF, Varghese AM, Ou SH, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res 2013;19:4273-81. 10.1158/1078-0432.CCR-13-0318 - DOI - PMC - PubMed
    1. Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol 2009;22:508-15. 10.1038/modpathol.2009.2 - DOI - PubMed
    1. Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;13:1011-9. 10.1016/S1470-2045(12)70344-3 - DOI - PMC - PubMed
    1. Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703. 10.1056/NEJMoa1006448 - DOI - PMC - PubMed

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