Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep;37(9):1043-1046.
doi: 10.1038/jp.2017.89. Epub 2017 Jun 15.

Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension

L B DeVries  1 , R J Heyne  1 , C Ramaciotti  2 , L S Brown  3 , M A Jaleel  1 , V S Kapadia  1 , P J Burchfield  1 , L P Brion  1
Affiliations

Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension

L B DeVries et al. J Perinatol. 2017 Sep.

Abstract

Objective: To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as ⩾28 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.

Study design: Single institution retrospective birth cohort of preterm infants with gestational age (GA) 230/7 to 366/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.

Results: Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).

Conclusion: Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.

PubMed Disclaimer

References

    1. Pediatrics. 2012 Mar;129(3):e682-9 - PubMed
    1. Am J Ther. 2012 Sep;19(5):377-83 - PubMed
    1. Anesth Analg. 2010 Nov;111(5):1110-6 - PubMed
    1. Anesthesiol Clin. 2014 Mar;32(1):157-73 - PubMed
    1. Pediatrics. 2010 Feb;125(2):e214-24 - PubMed

LinkOut - more resources