Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 15;36(1):26.
doi: 10.1186/s40101-017-0143-9.

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Yuji Shimizu  1   2 , Shimpei Sato  3 , Jun Koyamatsu  4 , Hirotomo Yamanashi  4 , Mako Nagayoshi  5 , Koichiro Kadota  5 , Shin-Ya Kawashiri  5 , Takahiro Maeda  5   4
Affiliations

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Yuji Shimizu et al. J Physiol Anthropol. .

Abstract

Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.

Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60-69 years who participated in general health checkup.

Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022.

Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.

Keywords: Circulating CD34-positive cell; HDL-cholesterol; Hypertension.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kitamura A, Yamagishi K, Imano H, Kiyama M, Cui R, Ohira T, Umesawa M, Muraki I, Sankai T, Saito I, Iso H; CIRCS Investigators. Impact of hypertension and subclinical organ damage on the incidence of cardiovascular disease among Japanese residents at the population and individual levels. The Circulatory Risk in Communities Study (CIRCS). Circ J. 2017. [Epub ahead of print]. - PubMed
    1. Emerging Risk Factors Collaboration. Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, Collins R, Thompson SG, Danesh J. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993–2000. doi: 10.1001/jama.2009.1619. - DOI - PMC - PubMed
    1. Oda E, Kawai R. High-density lipoprotein cholesterol is positively associated with hypertension in apparently healthy Japanese men and women. Br J Biomed Sci. 2011;68:29–33. doi: 10.1080/09674845.2011.11732838. - DOI - PubMed
    1. Dohi Y. Hypertension and oxidative stress. Nagoya Med J. 2010;51:153–158.
    1. Higashi Y, Sueda T, Yoshizumi M. Role of angiotensin II-related oxidative stress and nitric oxide in endothelial function in hypertension. J Jpn Coll Angiol. 2003;43:47–52.