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. 2017 Jun 15;36(1):26.
doi: 10.1186/s40101-017-0143-9.

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Yuji Shimizu  1   2 , Shimpei Sato  3 , Jun Koyamatsu  4 , Hirotomo Yamanashi  4 , Mako Nagayoshi  5 , Koichiro Kadota  5 , Shin-Ya Kawashiri  5 , Takahiro Maeda  5   4
Affiliations

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Yuji Shimizu et al. J Physiol Anthropol. .

Abstract

Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.

Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60-69 years who participated in general health checkup.

Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022.

Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.

Keywords: Circulating CD34-positive cell; HDL-cholesterol; Hypertension.

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