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Review
. 2017 Jun 15;45(3):683-691.
doi: 10.1042/BST20160158.

How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

David M J Lilley  1
Affiliations
Review

How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

David M J Lilley. Biochem Soc Trans. .

Abstract

Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic groupings to emerge.

Keywords: catalysis; general acid–base catalysis; metal ions; ribozymes.

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