Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 3;8(1):23-33.
doi: 10.1007/s13167-017-0081-y. eCollection 2017 Mar.

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Eden Avishai  1 , Kristina Yeghiazaryan  2 , Olga Golubnitschaja  2
Affiliations
Review

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Eden Avishai et al. EPMA J. .

Abstract

Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH. Current statistics demonstrate that both categories are increasingly presented in the populations, which causes dramatic socio-economic burden to the healthcare sector and society at large. Consequently, innovative concepts by predictive, preventive and personalised medicine are crucial to be implemented in the area. Individual risk factors, causality, functional interrelationships, molecular signature, predictive diagnosis, and primary and secondary prevention are thoroughly analysed followed by the expert recommendations in this paper.

Keywords: Cancer; Cardio-vascular disease; Diabetes; Flammer syndrome; Impaired healing; Predictive preventive personalised medicine; Wound.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of informed consent

Patients have not been involved in the study

Statement of human and animal rights

No experiments have been performed including patients and/or animals.

References

    1. Mathieu D, Linke JC, Wattel F. Non-healing wounds. In: Mathieu D, editor. Handbook on hyperbaric medicine. Dordrecht: Springer Netherlands; 2006. pp. 401–28.
    1. Lorenz HP, Longaker MT. Wounds: biology, pathology, and management. In: Norton JA, Barie PS, Bollinger RR, Chang AE, Lowry SF, Mulvihill SJ, editors. Surgery: basic science and clinical evidence. New York: Springer New York; 2008. pp. 191–208.
    1. Stolzenburg-Veeser L, Golubnitschaja O. Mini-encyclopaedia of the wound healing repertoire for multiprofessional considerations. J Proteomics. 2017;Submitted. - PubMed
    1. Nunan R, Harding KG, Martin P. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech. 2014;7(11):1205–13. doi: 10.1242/dmm.016782. - DOI - PMC - PubMed
    1. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127(3):514–25. doi: 10.1038/sj.jid.5700701. - DOI - PubMed