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Review
. 2015 Aug 25:1:12.
doi: 10.1186/s40738-015-0005-2. eCollection 2015.

Potential causes of subfertility in patients with intramural fibroids

Bruce D Pier  1 , G Wright Bates  1
Affiliations
Review

Potential causes of subfertility in patients with intramural fibroids

Bruce D Pier et al. Fertil Res Pract. .

Abstract

Background: Intramural leiomyomas have been long debated as a potential cause of infertility and pregnancy loss.

Findings: Previous research has linked intramural fibroids to defective implantation, as well as to abnormal peristaltic events of the uterine smooth muscle. Previous reports describe the effects of intramural fibroids on normal human fertility and early pregnancy loss, specifically in regards to implantation failure.

Conclusion: A thorough understanding of prior research may direct new research focus, leading to better understanding of leiomyoma-associated infertility.

Keywords: Fibroids; Implantation; Leiomyoma; Pseudocapsule; Uterine peristalsis.

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Figures

Fig. 1
Fig. 1
Potential causes of decreased fertility and  pregnancy loss in patients with intramural fibroids. (IMF- intramural fibroid, PC- fibroid pseudocapsule, JZ- uterine junctional zone, ES- endometrium, ER- estrogen receptor, PR- progesterone receptor, uNK- uterine natural killer cells.)
See this image and copyright information in PMC

References

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