Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun;28(3):288-295.
doi: 10.1007/s12028-017-0416-5.

The Role of Mast Cells in Intracerebral Hemorrhage

Mustafa Yehya  1 , Michel T Torbey  2   3
Affiliations
Review

The Role of Mast Cells in Intracerebral Hemorrhage

Mustafa Yehya et al. Neurocrit Care. 2018 Jun.

Abstract

Mast cells are first responders to intracerebral hemorrhage. They release potent mediators that can disrupt the blood-brain barrier promoting injury, vasogenic edema formation, and hematoma exacerbation. Also, mast cells recruit other inflammatory cells that maintain and amplify brain damage. Given their early role in the cascade of events in intracerebral hemorrhage, mast cells may offer an alternative target for antichemotactic interventions.

Keywords: Blood–brain barrier; Cytokines; Edema; Inflammation; Intracerebral hemorrhage; Mast cells.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Graphical description of the time sensitive mast cell activation process and the inflammatory cascade after intracerebral hemorrhage.
See this image and copyright information in PMC

References

    1. Ghably J, Saleh H, Vyas H, Peiris E, Misra N, Krishnaswamy G. Paul Ehrlich's mastzellen: a historical perspective of relevant developments in mast cell biology. Methods in molecular biology. 2015;1220:3–10. - PubMed
    1. Nelissen S, Lemmens E, Geurts N, Kramer P, Maurer M, Hendriks J, Hendrix S. The role of mast cells in neuroinflammation. Acta neuropathologica. 2013;125(5):637–650. - PubMed
    1. Collington SJ, Williams TJ, Weller CL. Mechanisms underlying the localisation of mast cells in tissues. Trends in Immunology. 2011;32(10):478–485. - PubMed
    1. Silver R, Curley JP. Mast cells on the mind: new insights and opportunities. Trends in neurosciences. 2013;36(9):513–521. - PubMed
    1. Ribatti D. The crucial role of mast cells in blood-brain barrier alterations. Experimental cell research. 2015;338(1):119–125. - PubMed

Publication types

LinkOut - more resources