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. 1985 Feb;10(1):21-8.
doi: 10.2131/jts.10.21.

Evaluation of the induction of hepatic drug-metabolizing enzymes in the rat and mouse treated with temazepam using trimethadione as the indicator

Y F Kitagawa, M Katahira, K Matsuda, E Tanaka, T Yoshida, Y Kuroiwa
Free article

Evaluation of the induction of hepatic drug-metabolizing enzymes in the rat and mouse treated with temazepam using trimethadione as the indicator

Y F Kitagawa et al. J Toxicol Sci. 1985 Feb.
Free article

Abstract

In the present paper we report the effect of high doses of temazepam on drug-metabolism induction in rat and mouse. Temazepam induced a dose-dependent and reversible increase of hepatic microsomal drug-metabolizing enzymes in the rat, dose-correlated increase of dimethadione/trimethadione ratios in plasma of the rat, and dose-related shortening of hexobarbital-induced sleeping time in the mouse. In this study trimethadione is considered a good indicator for estimating the state of hepatic enzyme induction.

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