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Review
. 2017 Sep:89:84-99.
doi: 10.1016/j.molimm.2017.05.028. Epub 2017 Jun 15.

The link between morphology and complement in ocular disease

Affiliations
Review

The link between morphology and complement in ocular disease

Camilla Mohlin et al. Mol Immunol. 2017 Sep.

Abstract

The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases. The potential benefits of complement inhibition in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica are abundant, as are those of further research to improve our understanding of complement-mediated injury in these diseases.

Keywords: Age-related macular degeneration; Complement; Eye; Glaucoma; Morphology; Neuromyelitis optica; Uveitis.

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