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Review
. 2017 Aug;28(8):587-596.
doi: 10.1016/j.tem.2017.05.003. Epub 2017 Jun 13.

Tumour-Derived Human Growth Hormone As a Therapeutic Target in Oncology

Jo K Perry  1 , Zheng-Sheng Wu  2 , Hichem C Mertani  3 , Tao Zhu  4 , Peter E Lobie  5
Affiliations
Review

Tumour-Derived Human Growth Hormone As a Therapeutic Target in Oncology

Jo K Perry et al. Trends Endocrinol Metab. 2017 Aug.

Abstract

The growth hormone (GH) and insulin-like growth factor-1 (IGF1) axis is the key regulator of longitudinal growth, promoting postnatal bone and muscle growth. The available data suggest that GH expression by tumour cells is associated with the aetiology and progression of various cancers such as endometrial, breast, liver, prostate, and colon cancer. Accordingly there has been increased interest in targeting GH-mediated signal transduction in a therapeutic setting. Because GH has endocrine, autocrine, and paracrine actions, therapeutic strategies will need to take into account systemic and local functions. Activation of related hormone receptors and crosstalk with other signalling pathways are also key considerations.

Keywords: IGF1; acromegaly; cancer; cancer stem cells; growth hormone.

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