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Comment
. 2017 Jul 3;36(13):1803-1805.
doi: 10.15252/embj.201797465. Epub 2017 Jun 16.

OH MYeloid! Immune cells wreaking havoc on brain homeostasis

Liana Bonanno  1 , Tony Wyss-Coray  2   3   4
Affiliations
Comment

OH MYeloid! Immune cells wreaking havoc on brain homeostasis

Liana Bonanno et al. EMBO J. .

Abstract

Genetic mutations responsible for neurodegenerative Nasu‐Hakola disease have been localized to the gene TREM2 and its adaptor DAP12, but it remained unclear what causes the brain to deteriorate. In this issue of The EMBO Journal, Kleinberger et al (2017) provide intriguing evidence suggesting a TREM2 mutation alone can lead to striking microglial dysfunction and precipitate changes in cerebral blood flow and metabolism in mice.

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Figures

Figure 1
Figure 1. Alteration in the brain milieu in response to TREM2 p.T66M mutation
The normal aging environment (top) in response to proper TREM2 expression, signaling, and shedding of soluble TREM2 into the circulation. The system shows adequate blood flow, glucose uptake, and nodules of reactive microglia. In the case of the TREM2 p.T66M mutation (bottom), microglia and peripheral macrophages loose surface expression of TREM2, as it is accumulated intracellularly. This leads to decreased levels of soluble TREM2, decreased cerebral blood flow, decreased glucose uptake, and decreased microglia nodule formation.
See this image and copyright information in PMC

Comment on

References

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