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Review
. 2018 Feb;66(1):45-54.
doi: 10.1007/s00005-017-0477-3. Epub 2017 Jun 16.

Skin Immunity

Agata Matejuk  1   2
Affiliations
Review

Skin Immunity

Agata Matejuk. Arch Immunol Ther Exp (Warsz). 2018 Feb.

Abstract

Skin is the largest organ of the body with a complex network of multitude of cell types that perform plastic and dynamic cellular communication to maintain several vital processes such as inflammation, immune response including induction of tolerance and disease prevention, wound healing, and angiogenesis. Of paramount importance are immunological functions of the skin that protect from harmful exposure coming from external and internal environments. Awareness of skin immunity can provide a better comprehension of inflammation, autoimmunity, cancer, graft-versus-host disease, vaccination, and immunotherapy approaches. This paper will update on what we currently know about immune sentinels contributing to skin immunity.

Keywords: Dermis; Epidermis; Hypoxia; Immune response; Skin.

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Conflict of interest statement

The author declare that she has no conflict of interest.

References

    1. Ackermann L, Harvima IT, Pelkonen J, et al. Mast cells in psoriatic skin are strongly positive for interferon-gamma. Br J Dermatol. 1999;140:624–633. doi: 10.1046/j.1365-2133.1999.02760.x. - DOI - PubMed
    1. Agerberth B, Charo J, Werr J, et al. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood. 2000;96:3086–3093. - PubMed
    1. Agius E, Lacy KE, Vukmanovic-Stejic M, et al. Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med. 2009;206:1929–1940. doi: 10.1084/jem.20090896. - DOI - PMC - PubMed
    1. Ahmadzadeh M, Felipe-Silva A, Heemskerk B, et al. FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions. Blood. 2008;112:4953–4960. doi: 10.1182/blood-2008-06-163048. - DOI - PMC - PubMed
    1. Albanesi C, Scarponi C, Giustizieri ML, et al. Keratinocytes in inflammatory skin diseases. Curr Drug Targets Inflamm Allergy. 2005;4:329–334. doi: 10.2174/1568010054022033. - DOI - PubMed

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