Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;31(2):171-179.
doi: 10.1016/j.bpg.2017.04.001. Epub 2017 Apr 12.

Hypo- and normothermic perfusion of the liver: Which way to go?

Jasmijn Selten  1 , Andrea Schlegel  2 , Jeroen de Jonge  3 , Philipp Dutkowski  4
Affiliations
Review

Hypo- and normothermic perfusion of the liver: Which way to go?

Jasmijn Selten et al. Best Pract Res Clin Gastroenterol. 2017 Apr.

Abstract

The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.

Keywords: HOPE; Hypothermic; Liver transplantation; Machine perfusion; Normothermic; Preservation.

PubMed Disclaimer

LinkOut - more resources