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Review
. 2018 Apr:164:136-144.
doi: 10.1016/j.thromres.2017.06.011. Epub 2017 Jun 12.

Current understanding of the pathophysiology of chronic thromboembolic pulmonary hypertension

Smriti Sharma  1 , Irene M Lang  2
Affiliations
Review

Current understanding of the pathophysiology of chronic thromboembolic pulmonary hypertension

Smriti Sharma et al. Thromb Res. 2018 Apr.

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension arising from fibrotic obliteration of major pulmonary arteries. Pro-thrombotic states, large clot burden and impaired dissolution are believed to contribute to the occurrence and progression of thrombosis after an acute pulmonary embolic event. Recent data utilizing several models have facilitated the understanding of clot resolution. This review summarizes current knowledge on pathophysiological mechanisms of major vessel occlusion in CTEPH.

Keywords: CTEPH; Pathophysiology; Thrombus resolution.

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