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Review
. 2018 Jun;33(6):925-933.
doi: 10.1007/s00467-017-3701-9. Epub 2017 Jun 17.

Emerging biomarkers of chronic kidney disease in children

Jason H Greenberg  1   2 , Aadil Kakajiwala  3 , Chirag R Parikh  4   5   6 , Susan Furth  3
Affiliations
Review

Emerging biomarkers of chronic kidney disease in children

Jason H Greenberg et al. Pediatr Nephrol. 2018 Jun.

Abstract

Chronic kidney disease (CKD) has become a significant public health concern, as it is associated with substantial morbidity. Prior research has evaluated multiple novel CKD biomarkers to supplement serum creatinine and proteinuria. The ultimate goal of this research is to find biomarkers that can be used to accurately predict CKD progression and to better time outpatient follow-up, and referral for transplant. Also, an optimal panel of biomarkers can augment the predictive value of proteinuria and serum creatinine by enriching patient enrollment in clinical trials. In this review, we discuss salient findings on 12 candidate plasma and urine biomarkers and their reported association with CKD. We explore the common pathways of CKD progression and the pathophysiologic processes of tubulointerstitial injury, inflammation, repair, and fibrosis that are potentially classified by specific biomarkers. We describe both pediatric and adult findings and highlight the paucity of pediatric research in CKD progression. It will be important for cohorts with longitudinal follow-up to evaluate these CKD biomarkers for potential use in pediatric clinical trials and routine CKD management.

Keywords: Biomarker; CKD; CKD progression; ESRD; Pediatrics.

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Conflict of interest statement

Conflict of Interest: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Novel biomarkers of chronic kidney disease (CKD) progression: mediators or byproducts associated with the pathophysiology of glomerular filtration rate (GFR) decline
See this image and copyright information in PMC

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