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. 2017 Jul 5;139(26):8808-8811.
doi: 10.1021/jacs.7b04985. Epub 2017 Jun 23.

An OFF-ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

Beatriz Lozano-Torres  1   2   3   4 , Irene Galiana  1   2   3   4 , Miguel Rovira  5 , Eva Garrido  1   2   3   4 , Selim Chaib  5 , Andrea Bernardos  1   2   3   4 , Daniel Muñoz-Espín  5   6 , Manuel Serrano  5 , Ramón Martínez-Máñez  1   2   3   4 , Félix Sancenón  1   2   3   4
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Free article

An OFF-ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

Beatriz Lozano-Torres et al. J Am Chem Soc. .
Free article

Abstract

A naphthalimide-based two-photon probe (AHGa) for the detection of cell senescence is designed. The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galactose bonded to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond. Probe AHGa is transformed into AH in senescent cells resulting in an enhanced fluorescent emission intensity. In vivo detection of senescence is validated in mice bearing tumor xenografts treated with senescence-inducing chemotherapy.

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