Bioengineering strategies for inducing tolerance in autoimmune diabetes

Steinunn Baekkeskov¹, Jeffrey A Hubbell², Edward A Phelps³

Affiliations

¹ Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; Departments of Medicine and Microbiology/Immunology, Diabetes Center, 513 Parnassus Ave, 20159, Box 0534, University of California San Francisco, San Francisco, CA, 94143, USA.
² Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; Institute for Molecular Engineering, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60615, USA.
³ Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, P.O. Box 116131, Gainesville, FL 32611, USA. Electronic address: ephelps@bme.ufl.edu.

PMID: 28625830
DOI: 10.1016/j.addr.2017.06.007

Review

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Steinunn Baekkeskov et al. Adv Drug Deliv Rev. 2017.

. 2017 May 15:114:256-265.

doi: 10.1016/j.addr.2017.06.007. Epub 2017 Jun 15.

Authors

Steinunn Baekkeskov¹, Jeffrey A Hubbell², Edward A Phelps³

Affiliations

¹ Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; Departments of Medicine and Microbiology/Immunology, Diabetes Center, 513 Parnassus Ave, 20159, Box 0534, University of California San Francisco, San Francisco, CA, 94143, USA.
² Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; Institute for Molecular Engineering, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60615, USA.
³ Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Building SV 3826, Station 19, CH-1015 Lausanne, Switzerland; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, P.O. Box 116131, Gainesville, FL 32611, USA. Electronic address: ephelps@bme.ufl.edu.

PMID: 28625830
DOI: 10.1016/j.addr.2017.06.007

Abstract

Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.

Keywords: Autoimmunity; Biomaterials; Tolerance; Type 1 diabetes.

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Bioengineering strategies for inducing tolerance in autoimmune diabetes

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Bioengineering strategies for inducing tolerance in autoimmune diabetes

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