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Comment
. 2017 Jul 3;149(7):683-687.
doi: 10.1085/jgp.201711826. Epub 2017 Jun 16.

No fuzzy space for intracellular Na+ in healthy ventricular myocytes

Frank B Sachse  1 , Robert Clark  2 , Wayne R Giles  3
Affiliations
Comment

No fuzzy space for intracellular Na+ in healthy ventricular myocytes

Frank B Sachse et al. J Gen Physiol. .

Abstract

Sachse et al. highlight work that reveals a Na+-dependent inactivation mechanism in the Na+/K+ pump.

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Figures

Figure 1.
Figure 1.
Simulated action potential and currents of a human atrial myocyte. The model of Grandi et al. (2011) was used to calculate the (A) membrane voltage and underlying currents at a pacing rate of 1 Hz. The action potential was triggered by a stimulus current at t = 50 ms. The inward rectifier K+ current is shown in B. Currents through the Na+-K+ pump and Na+-Ca2+ exchanger are displayed in C and D, respectively.
See this image and copyright information in PMC

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