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Comment
. 2017 Aug;14(8):646-648.
doi: 10.1038/cmi.2017.33. Epub 2017 Jun 19.

Human γδ T cells: rapid, stable and clonally reactive

Avi-Hai Hovav  1
Affiliations
Comment

Human γδ T cells: rapid, stable and clonally reactive

Avi-Hai Hovav. Cell Mol Immunol. 2017 Aug.
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Dynamics of γδ T-cell receptor (TCR) repertoires. (a) After birth, the TCR repertoires of γδ T cells present high diversity. This changes during life as the γδ TCR repertoires become more focused and narrow, likely due to environmental and genetic factors. The adult γδ TCR repertoires remain remarkably stable in healthy adults. (b) In individuals undergoing transplantation of hematopoietic stem cells, γδ T cells are rapidly reconstituted in the host and present γδ TCR repertoires typical to adults. This newly generated repertoire differs greatly from the γδ TCR repertoires of both the donor and recipient before the transplantation, suggesting that γδ T cells differentiate de novo in the recipient’s thymus. Nevertheless, donor-derived γδ T cells also contribute directly to the reconstituted γδ T-cell pools, probably via homeostatic proliferation. (c) Cytomegalovirus (CMV) infection or reactivation represents an intense challenge to the immune system. CMV-reactive γδ T-cell clones exist in the γδ TCR repertoires of stem cell recipients and, upon activation, massively proliferate in an antigen-specific manner, leading to a significant increase in frequency among total γδ TCR repertoires.
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