A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma

Abstract

A 24-year-old woman presented with a 5-month history of a left flank mass that was painful on palpation. Magnetic resonance imaging revealed a 10.0 × 6.0 × 2.5 cm mass consistent with lipoma. A fatty lobulated mass was excised and subjected to H&E staining and immunohistochemical analyses. The specimen consisted of mature univacuolated adipocytic cells, with intermixed multivacuolated eosinophilic granular cells. No atypia or hyperchromasia was identified. Most of the cells were S100 positive and Ki-67 immunonegative. A diagnosis of a lipoma-like hibernoma was rendered. Hibernomas are rare benign lipomatous tumors that show differentiation toward brown fat. The lipoma-like hibernoma subtype is rare and can be misdiagnosed as atypical lipoma or well-differentiated liposarcoma. Here we describe an example of this rare tumor.

Keywords: Atypical lipoma; Hibernoma; Lipoma-like hibernoma; Well-differentiated liposarcoma.

Fig. 1

Representative H&E and immunohistochemistry results for the lipoma-like hibernoma. a, b Low-power (a) and high-power (b) H&E views of the lipoma-like hibernoma. c, d High-power views of S100 (c) and KI-67 (d) immunohistochemistry. The Ki-67 immunohistochemistry shows only the counterstain.