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Case Reports
. 2017:2017:9871687.
doi: 10.1155/2017/9871687. Epub 2017 May 24.

A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component

Quang Duy Pham  1   2 , Ichiro Mori  1 , Robert Y Osamura  3
Affiliations
Case Reports

A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component

Quang Duy Pham et al. Case Rep Pathol. 2017.

Abstract

Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) is defined as mixed epithelial neoplasms composed of both neuroendocrine and nonneuroendocrine components with variable proportions for each component. Neuroendocrine component can show morphological features including well- or poorly differentiated neuroendocrine neoplasms and nonneuroendocrine component can present different tumor types depending on the site of origin. Recently, studies of tumors have shown that MiNENs are not as rare as our traditional belief, due to the wide application for immunohistochemistry. However, our knowledge of MiNENs is still limited. There is no universal consensus about nomenclature, classification, and guideline of treatment. Hereby, we would like to present a case report of gastric MiNEN with aggressive neuroendocrine component to contribute a small part towards common understanding of gastric MiNENs.

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Figures

Figure 1
Figure 1
Microscopy of gastric tumor on biopsy.
Figure 2
Figure 2
Immunoprofile of gastric tumor performed on biopsy.
Figure 3
Figure 3
Microscopy of gastric tumor on autopsy.
Figure 4
Figure 4
Immunoprofile of gastric tumor performed on autopsy.
Figure 5
Figure 5
Immunoprofile of liver lesion performed on autopsy.
See this image and copyright information in PMC

References

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