Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug;17(8):469-482.
doi: 10.1038/nri.2017.64. Epub 2017 Jun 19.

The unique immunological and microbial aspects of pregnancy

Gil Mor  1 , Paulomi Aldo  1 , Ayesha B Alvero  1
Affiliations

The unique immunological and microbial aspects of pregnancy

Gil Mor et al. Nat Rev Immunol. 2017 Aug.

Abstract

The comparison of the immunological state of pregnancy to an immunosuppressed host-graft model continues to lead research and clinical practice to ill-defined approaches. This Review discusses recent evidence that supports the idea that immunological responses at the receptive maternal-fetal interface are not simply suppressed but are instead highly dynamic. We discuss the crucial role of trophoblast cells in shaping not only the way in which immune cells respond to the invading blastocyst but also how they collectively react to external stimuli. We also discuss the role of the microbiota in promoting a tolerogenic maternal immune system and highlight how subclinical viral infections can disrupt this status quo, leading to pregnancy complications.

PubMed Disclaimer

References

    1. Am J Reprod Immunol. 2010 Jun;63(6):472-81 - PubMed
    1. Am J Reprod Immunol. 2017 Jul;78(1): - PubMed
    1. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7219-24 - PubMed
    1. Am J Reprod Immunol. 2015 May;73(5):445-59 - PubMed
    1. Front Immunol. 2014 Jun 23;5:285 - PubMed

LinkOut - more resources