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Clinical Trial
. 1985 Sep;142(9):1106-7.
doi: 10.1176/ajp.142.9.1106.

Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia

D A Brizer, N Hartman, J Sweeney, R B Millman
Clinical Trial

Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia

D A Brizer et al. Am J Psychiatry. 1985 Sep.

Abstract

In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.

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