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. 2017 Aug;13(8):836-838.
doi: 10.1038/nchembio.2411. Epub 2017 Jun 19.

A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate

Yi-Ling Du  1   2 , Hai-Yan He  2 , Melanie A Higgins  2 , Katherine S Ryan  2
Affiliations

A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate

Yi-Ling Du et al. Nat Chem Biol. 2017 Aug.

Abstract

Molecules containing a nitrogen-nitrogen (N-N) linkage have a variety of structures and biological activities; however, no enzyme has yet been demonstrated to catalyze N-N bond formation in an organic molecule. Here we report that the heme-dependent enzyme KtzT from Kutzneria sp. 744 catalyzes N-N bond formation in the biosynthesis of piperazate, a building block for nonribosomal peptides.

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