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. 2017 Jul 17;56(30):8677-8680.
doi: 10.1002/anie.201702429. Epub 2017 Jun 19.

Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes

Masaru Kondo  1   2 , Masashi Omori  1 , Tsubasa Hatanaka  3 , Yasuhiro Funahashi  3 , Shuichi Nakamura  1   2
Affiliations

Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes

Masaru Kondo et al. Angew Chem Int Ed Engl. .

Abstract

The first highly enantioselective reaction of allenylnitriles with imines has been developed. Excellent yields and enantioselectivities were observed for the reaction with various imines using chiral Phebim-PdII complexes. This process offers a simple and efficient synthetic route for various functionalized α-vinylidene-β-aminonitriles and their derivatives.

Keywords: Lewis acids; allenyl compounds; asymmetric synthesis; pincer complex.

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