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. 2017 Jul;23(7):1160-1163.
doi: 10.3201/eid2307.161638.

Locally Acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013

Justin A Ellem, Andrew N Ginn, Sharon C-A Chen, John Ferguson, Sally R Partridge, Jonathan R Iredell

Locally Acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013

Justin A Ellem et al. Emerg Infect Dis. 2017 Jul.

Abstract

We identified discrete importation events of the mcr-1 gene on incompatibility group IncI2 plasmids in Escherichia coli isolated from patients in New South Wales, Australia, in 2011 and 2013. mcr-1 is present in a small minority of colistin-resistant Enterobacteriaceae and appears not to be established locally.

Keywords: Australia; Escherichia coli; IncI2 plasmid; antimicrobial resistance; bacteria; colistin; colistin-resistant Enterobacteriaceae; importation events; mcr-1; plasmid.

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Figures

Figure
Figure
Differences in promoter and ribosome binding site regions of mcr-1 in plasmids from Escherichia coli in Australia (indicated by arrows) and in other sequences available from GenBank. The sequences end with the ATG start codon of mcr-1 and a second ATG codon that follows it. The −35 and −10 regions of the proposed promoter (11) are indicated by arrows. The numbers to the right indicate how many times each variant has been seen among available sequences.
See this image and copyright information in PMC

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