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. 1985 Jun;19(6):839-42.
doi: 10.1111/j.1365-2125.1985.tb02725.x.

Effects of end stage renal disease and aluminium hydroxide on triazolam pharmacokinetics

P D Kroboth, R B Smith, M R Silver, R Rault, M I Sorkin, J B Puschett, R P Juhl

Effects of end stage renal disease and aluminium hydroxide on triazolam pharmacokinetics

P D Kroboth et al. Br J Clin Pharmacol. 1985 Jun.

Abstract

Triazolam 0.5 mg was administered to 11 dialysis patients and 11 age, weight and sex matched controls. Peak plasma concentrations (Cmax) were higher in control subjects, but there were no other differences between the groups. When dialysis patients took triazolam with 3600 mg aluminum hydroxide suspension, Cmax and AUC were increased into the range observed in control subjects. It appears that triazolam can be used at normal doses in patients with renal dysfunction, without regard to interaction with aluminum hydroxide gel, or to alterations in elimination.

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References

    1. Clin Pharmacol Ther. 1976 Feb;19(2):234-9 - PubMed
    1. Clin Pharmacol Ther. 1978 Nov;24(5):600-9 - PubMed
    1. Clin Pharmacol Ther. 1981 Jan;29(1):81-93 - PubMed
    1. Clin Pharmacol Ther. 1984 Sep;36(3):379-83 - PubMed
    1. J Pharm Sci. 1982 Dec;71(12):1328-34 - PubMed

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