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Review
. 2017 Jun 14:15:12.
doi: 10.1186/s12948-017-0068-1. eCollection 2017.

Association between HMGB1 and asthma: a literature review

Egidio Imbalzano  1 , Sebastiano Quartuccio  1 , Eleonora Di Salvo  2 , Teresa Crea  1 , Marco Casciaro  3 , Sebastiano Gangemi  3
Affiliations
Review

Association between HMGB1 and asthma: a literature review

Egidio Imbalzano et al. Clin Mol Allergy. .

Abstract

Background: Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation.

Objective: This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma.

Methods: We reviewed experimental studies that investigated the pathogenetic role of HMGB in bronchial airway hyper-responsiveness, inflammation and the correlation between HMGB1 level and asthma.

Results: A total of 19 studies assessing the association between HMGB1 and asthma were identified.

Conclusions: What emerged from this literature review was the confirmation of HMGB-1 involvement in diseases characterised by chronic inflammation, especially in pulmonary pathologies. Findings reported suggest a potential role of the alarmin in being a stadiation method and a marker of therapeutic efficacy; finally, inhibiting HMGB1 in humans in order to contrast inflammation should be the aim for future further studies.

Keywords: Alarmin; Allergy; Asthma; COPD; Cytokines; HMGB-1; Inflammation; RAGE.

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Figures

Fig. 1
Fig. 1
Intracellular and extracellular HMGB-1 main interactions
See this image and copyright information in PMC

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References

    1. Goodwin GH, Johns EW. Are the high mobility group non-histone chromosomal proteins associated with ‘active’ chromatin? Biochim Biophys Acta. 1978;519:279–284. doi: 10.1016/0005-2787(78)90081-3. - DOI - PubMed
    1. Sohun M, Shen H. The implication and potential applications of high-mobility group box 1 protein in breast cancer. Ann Transl Med. 2016;4:217. doi: 10.21037/atm.2016.05.36. - DOI - PMC - PubMed
    1. Landsman D, Bustin M. A signature for the HMG-1 box DNA-binding proteins. Bioessays. 1993;15:539–546. doi: 10.1002/bies.950150807. - DOI - PubMed
    1. Chung HW, Lim JB, Jang S, Lee KJ, Park KH, Song SY. Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. Cancer Sci. 2012;103:1714–1721. doi: 10.1111/j.1349-7006.2012.02358.x. - DOI - PMC - PubMed
    1. Romani M, Rodman TC, Vidali G, Bustin M. Serological analysis of species specificity in the high mobility group chromosomal proteins. J Biol Chem. 1979;254:2918–2922. - PubMed

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