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. 2017 Jun 20;9(6):632.
doi: 10.3390/nu9060632.

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Mikael Fogelholm  1 , Thomas Meinert Larsen  2 , Margriet Westerterp-Plantenga  3 , Ian Macdonald  4 , J Alfredo Martinez  5   6 , Nadka Boyadjieva  7 , Sally Poppitt  8 , Wolfgang Schlicht  9 , Gareth Stratton  10 , Jouko Sundvall  11 , Tony Lam  12 , Elli Jalo  13 , Pia Christensen  14 , Mathijs Drummen  15 , Elizabeth Simpson  16 , Santiago Navas-Carretero  17   18 , Teodora Handjieva-Darlenska  19 , Roslyn Muirhead  20 , Marta P Silvestre  21 , Daniela Kahlert  22 , Laura Pastor-Sanz  23 , Jennie Brand-Miller  24 , Anne Raben  25
Affiliations

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Mikael Fogelholm et al. Nutrients. .

Abstract

Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018.

Keywords: carbohydrate; diet; glycaemic index; obesity; physical activity; protein.

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Conflict of interest statement

The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Figures

Figure 1
Figure 1
PREVIEW intervention: the general study design.
Figure 2
Figure 2
PREVIEW intervention: the subjects’ flowchart.
See this image and copyright information in PMC

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