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Review
. 2017 Jun 20;22(6):858.
doi: 10.3390/molecules22060858.

Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential

Jaqueline Moraes Bazioli  1 , Luciana Da Silva Amaral  2 , Taícia Pacheco Fill  3 , Edson Rodrigues-Filho  4
Affiliations
Review

Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential

Jaqueline Moraes Bazioli et al. Molecules. .

Abstract

Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen. All investigated strains share a great ability to produce bioactive secondary metabolites. Different authors have investigated this great capability and here we summarize the metabolic potential and the biological activities related to P. brasilianum's metabolites with diverse structures. They include secondary metabolites of an alkaloid nature, i.e., 2,5-diketopiperazines, cyclodepsipeptides, meroterpenoids and polyketides. Penicillium brasilianum is also described as a great source of enzymes with biotechnological application potential, which is also highlighted in this review. Additionally, this review will focus on several aspects of Penicillium brasilianum and interesting genomic insights.

Keywords: Penicillium brasilianum; biological activity; biotransformation; secondary metabolism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The biotechnological potential of Penicillium brasilianum.
See this image and copyright information in PMC

References

    1. Visagie C., Houbraken J., Frisvad J., Hong S.B., Klaassen C., Perrone G., Seifert K., Varga J., Yaguchi T., Samson R. Identification and nomenclature of the genus penicillium. Stud. Mycol. 2014;78:343–371. doi: 10.1016/j.simyco.2014.09.001. - DOI - PMC - PubMed
    1. Cho H.S., Hong S.B., Go S.J. First report of Penicillium brasilianum and P. daleae isolated from soil in Korea. Mycobiology. 2005;33:113–117. doi: 10.4489/MYCO.2005.33.2.113. - DOI - PMC - PubMed
    1. Kozlovskii A.G., Zhelifonova V.P., Antipova T.V. Fungi of the genus penicillium as producers of physiologically active compounds (review) Prikl. Biokhim. Mikrobiol. 2013;49:5–16. doi: 10.1134/S0003683813010092. - DOI - PubMed
    1. Ropars J., De la Vega R.R., Villavicencio M.L., Branca A. Diversity and mechanisms of genomic adaptation in penicillium. In: DeVries R.G., Andersen M.R., editors. Aspergillus and Penicillium in the Post-Genomic Era. Caister Academic Press; Lyngby, Denmark: 2016. pp. 27–42.
    1. Rancic A., Sokovic M., Karioti A., Vukojevic J., Skaltsa H. Isolation and structural elucidation of two secondary metabolites from the filamentous fungus Penicillium ochrochloron with antimicrobial activity. Environ. Toxicol. Pharmacol. 2006;22:80–84. doi: 10.1016/j.etap.2005.12.003. - DOI - PubMed

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