Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks
- PMID: 28633012
- DOI: 10.1016/j.devcel.2017.06.008
Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks
Abstract
Blood vessel shape is malleable and dynamically regulated. In two recent papers in Nature Cell Biology, Jin et al. (2017) and Sugden et al. (2017) show that endoglin alters endothelial cell shape or behavior in response to blood flow, thus regulating vessel structure.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.Nat Cell Biol. 2017 Jun;19(6):653-665. doi: 10.1038/ncb3528. Epub 2017 May 22. Nat Cell Biol. 2017. PMID: 28530658 Free PMC article.
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Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.Nat Cell Biol. 2017 Jun;19(6):639-652. doi: 10.1038/ncb3534. Epub 2017 May 22. Nat Cell Biol. 2017. PMID: 28530660 Free PMC article.
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