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. 2017 Nov;25(11):3457-3464.
doi: 10.1007/s00520-017-3768-7. Epub 2017 Jun 21.

Longitudinal perceptions of the side effects of chemotherapy in patients with gynecological cancer

Hui-Chun Hsu  1   2 , Su-Yu Tsai  1 , Shang-Liang Wu  3 , Shiow-Roug Jeang  1 , Mei-Yao Ho  2 , Wen-Shiung Liou  4   5   6 , An-Jen Chiang  7   8   9   10 , Tsung-Hsien Chang  11
Affiliations

Longitudinal perceptions of the side effects of chemotherapy in patients with gynecological cancer

Hui-Chun Hsu et al. Support Care Cancer. 2017 Nov.

Abstract

Purpose: This study aimed to assess the incidence and difference of side effects among six courses of chemotherapy (C/T) in gynecological cancer patients.

Methods: The study period was from Sep. 2010 to Dec. 2011 at the Kaohsiung Veterans General Hospital in Taiwan. The treating protocols, courses, and drugs of C/T in patient were considered according to the different malignant cancers and clinical conditions. The patient data of age, marriage status, education, religion, and experiences of C/T were collected. The patients' or their families' reported side effects of C/T were recorded daily from the beginning of C/T to the 10th day after C/T in each cycle and every course of C/T.

Results: Total 89 patients enrolled into the study received total 450 courses of C/T. The mean age was 54.52 ± 11.02. Ovarian cancer was the most common malignant disease (64.0%). The most often combination of drugs used was Taxol and carboplatin (40.9%). Patients complained peripheral numbness of limbs, with the highest incidence of 58.6%. The side effects with incidence about 50% were decreased fatigue (55.0%) and hair loss (49.9%). Other side effects with different levels of incidence were also noticed, such as lack of appetite, changes in taste, and muscle ache. The incidences of peripheral limb numbness and hair loss were increased with following courses of C/T. The high incidence of fatigue did not show variation between different courses of C/T.

Conclusion: This study revealed the incidence of side effects and occurrence timing during C/T in patients with gynecological cancer. These data provide substantial information to patients and their families to understand the potential side effects of C/T courses, which might increase their compliance in receiving adjuvant C/T. Relieving the side effects in C/T would be important to improve their quality of daily life and treatment willingness.

Keywords: CIPN; Chemotherapy; Gynecological cancer; Peripheral neuropathy; Side effects.

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