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Meta-Analysis
. 2017 Jul 17;109(13):1011-1019.
doi: 10.1002/bdr2.1043. Epub 2017 Jun 21.

Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta-Analysis

Mengying Wang  1 , Yuan Yuan  1 , Zifan Wang  1 , Dongjing Liu  1 , Zhuqing Wang  1 , Feng Sun  1 , Ping Wang  2 , Hongping Zhu  3 , Jing Li  3 , Tao Wu  1   4 , Terri H Beaty  5
Affiliations
Meta-Analysis

Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta-Analysis

Mengying Wang et al. Birth Defects Res. .

Abstract

Background: Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs.

Methods: The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevalence.

Results: A total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random-effects model of meta-analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1-1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1-4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p-value = 0.47).

Conclusion: The overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011-1019, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: meta-analysis; orofacial clefts; prevalence; systematic review.

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Figures

FIGURE 1
FIGURE 1
Flow chart of study selection.
FIGURE 2
FIGURE 2
Risk of quality assessment for all included studies.
FIGURE 3
FIGURE 3
Overall prevalence of orofacial clefts among live births in China.
FIGURE 4
FIGURE 4
Prevalence of orofacial clefts in different provinces in China
See this image and copyright information in PMC

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