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. 2016;88(11):121-127.
doi: 10.17116/terarkh20168811121-127.

[Use of succinate-containing agents in the treatment of infectious diseases]

[Article in Russian]
Affiliations

[Use of succinate-containing agents in the treatment of infectious diseases]

[Article in Russian]
E O Tikhonova et al. Ter Arkh. 2016.

Abstract

The review gives data that reveal the role of succinic acid in providing cells with energy and oxygen under hypoxic conditions. It presents the results of clinical and experimental studies to evaluate the efficacy of succinate-containing drugs in the combination therapy of infectious diseases. The spectrum of biological effects of these drugs, which is provided by the synergy of their active ingredients, is considered.

В обзоре приводятся данные, раскрывающие роль янтарной кислоты в обеспечении клеток энергией и кислородом в условиях гипоксии. Представлены результаты клинических и экспериментальных исследований по оценке эффективности применения препаратов, содержащих сукцинат, в комплексной терапии инфекционной патологии. Рассмотрен спектр биологических эффектов таких препаратов, обеспечиваемый синергизмом входящих в них активных компонентов.

Keywords: enteric infections; hypoxia; infectious diseases; succinate-containing drugs; succinic acid.

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