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Comment
. 2017 Jun 20;46(6):968-970.
doi: 10.1016/j.immuni.2017.05.010.

T-bet Runs INTERFERence

Vanja Lazarevic  1 , Susanne Szabo  2 , Laurie H Glimcher  3
Affiliations
Comment

T-bet Runs INTERFERence

Vanja Lazarevic et al. Immunity. .

Abstract

In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-γ signaling.

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Figures

Figure 1.
Figure 1.. T-bet Is a Negative Regulator of Type I IFN Response in CD4+ Th1 Cells
In the presence of IFN-γ, T-bet blocks the type I IFN response in CD4+ T cells by inhibiting the expression of type I IFN transcription factors (STAT1, STAT2, and IRF7) and approximately 26% of ISGs. In contrast, in CD4+ T cells deficient in T-bet (Tbx21−/−), IFN-γ treatment causes an upregulation of STAT1, STAT2, and IRF7 expression and enhancement of STAT2 binding at ISG regulatory regions, leading to elevated production of IFN-α and IFN-β. The IFN-α and IFN-β produced form a self-amplifying feed-forward loop that reinforces the type I IFN response.
See this image and copyright information in PMC

Comment on

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