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Comment
. 2017 Jun 20;46(6):974-976.
doi: 10.1016/j.immuni.2017.06.003.

The TORC that Gets the GC Cycling

Elissa K Deenick  1 , Stuart G Tangye  2
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Free article
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The TORC that Gets the GC Cycling

Elissa K Deenick et al. Immunity. .
Free article

Abstract

The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.

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