Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 21;22(1):21.
doi: 10.1186/s40001-017-0260-2.

Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

Ashraf Aminorroaya  1 , Rokhsareh Meamar  2 , Massoud Amini  3 , Awat Feizi  2   4 , Azamosadat Tabatabae  2 , Elham Faghih Imani  3
Affiliations

Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

Ashraf Aminorroaya et al. Eur J Med Res. .

Abstract

Background: The prevalence of thyroid dysfunction is high in Isfahan, an area of iodine sufficient in Iran. The aim of this study is to investigate the incidence of thyroid dysfunctions in adults of metropolitan Isfahan and to determine the role of thyroid autoantibodies.

Methods: In a population-based cohort study in 2006-2011, we measured TSH, T4, T3, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in 618 out of 2254 people who were euthyroid in 2006. The incidence rates per 1000 person-year (pr) were calculated. The odds ratio (OR), relative risk (RR), and 95% confidence interval (95% CI) were calculated based on logistic regression to quantify the potential predictors of thyroid dysfunction. The receiver-operator characteristic (ROC) analysis along with area under the curve (AUC) was used to determine the optimal cutoff values for baseline TPOAb and TgAb as predictors of thyroid dysfunction.

Results: Within a 6-year follow-up, the incidence rate of hypothyroidism was 3.3 in women and 2.1 in men while the incidence rate of hyperthyroidism was 3.8 in women and none in men per 1000 (person-year). A cutoff value of TPOAb at 38 IU/mL was obtained to differentiate the patients with hypothyroidism and hyperthyroidism, with specificity of 0.75 and sensitivity of 0.76, and AUC (CI 95%) of 0.882 (0.743-1.02), P = 0.01 and 0.817 (0.600-1.035) P = 0.033, respectively. There is a statistically significant association of hypothyroidism and hyperthyroidism with positive TPOAb [RR (CI 95%): 1.99 (1.27-3.13) and 2.20 (1.23-3.95), respectively].

Conclusions: The incidence rate of thyroid dysfunction is high in Isfahan, and higher TPOAb concentration is its strong predictor.

Keywords: Hyperthyroidism; Hypothyroidism; Incidence; Iran; TPO antibodies; Thyroid autoantibodies.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Thyroid peroxidase antibody (TPOAb) and thyroid globulin antibody (TgAb) levels in different thyroid function statuses of Isfahani adult people (n = 615) in 2011 who were euthyroid in 2006
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Canaris GJ, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526–534. doi: 10.1001/archinte.160.4.526. - DOI - PubMed
    1. Cappola AR, et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2006;295(9):1033–1041. doi: 10.1001/jama.295.9.1033. - DOI - PMC - PubMed
    1. Aminorroaya A, et al. The prevalence of thyroid dysfunction in an iodine-sufficient area in Iran. Arch Iran Med. 2009;12(3):262–270. - PubMed
    1. Leese GP, et al. Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the thyroid epidemiology audit and research study (TEARS) Clin Endocrinol (Oxf) 2008;68(2):311–316. - PubMed
    1. Strieder TG, et al. Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease. Clin Endocrinol (Oxf) 2003;59(3):396–401. doi: 10.1046/j.1365-2265.2003.01862.x. - DOI - PubMed

MeSH terms