Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May-Jun;22(3):212-217.
doi: 10.5863/1551-6776-22.3.212.

Extended Infusion of Piperacillin/Tazobactam in Children

Chad A Knoderer, Lauren C Karmire, Katie L Andricopulos, Kristen R Nichols

Extended Infusion of Piperacillin/Tazobactam in Children

Chad A Knoderer et al. J Pediatr Pharmacol Ther. 2017 May-Jun.

Abstract

Objectives: Extended-infusion piperacillin/tazobactam (TZP) has been associated with positive clinical outcomes in adults, but similar data in children are lacking. The objective of this study was to describe efficacy outcomes with pediatric patients receiving extended-infusion TZP.

Methods: This was a retrospective case series of children aged 1 month to 17 years who had documented Gram-negative infection and received extended-infusion TZP between April 2011 and March 2012. The primary outcome was 21-day clinical cure defined as negative follow-up cultures, where available, and infection resolution.

Results: Fifty children with a median (interquartile range [IQR]) age of 5 (2-9) years were included in the study. Patients received a median (IQR) TZP dose of 111.4 (100-112.5) mg/kg administered every 8 hours over 4 hours. Clinical and microbiologic cure were observed in 74% and 100% of patients, respectively. Patients not meeting criterial for 21-day clinical cure were younger (1 vs 7 years, p = 0.087) and had a longer length of hospital stay (23 vs 11 days, p = 0.037).

Conclusions: The majority of children in this cohort achieved 21-day clinical cure with extended-interval TZP. Those without clinical cure tended to be younger and critically ill. Additional comparative studies evaluating traditional and extended-infusion TZP in children are needed.

Keywords: beta-lactam; extended infusion; outcomes; pediatrics; piperacillin/tazobactam.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria. The authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. El-Mahallawy HA, El-Wakil M, Moneer MM, Shalaby L. . Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer. Pediatr Blood Cancer. 2011; 57( 2): 283– 288. - PubMed
    1. Qin X, Zerr DM, Weissman SJ, . et al. Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience. Antimicrob Agents Chemother. 2008; 52( 11): 3909– 3914. - PMC - PubMed
    1. Wisplinghoff H, Seifert H, Tallent SM, . et al. Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. Pediatr Infect Dis J. 2003; 22( 8): 686– 691. - PubMed
    1. Lee CY, Chen PY, Huang FL, Lin CF. . Microbiologic spectrum and susceptibility pattern of clinical isolates from the pediatric intensive care unit in a single medical center—6 years' experience. J Microbiol Immunol Infect. 2009; 42( 2): 160– 165. - PubMed
    1. Lodise TP, Lomaestro BM, Drusano GL. . Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on β-lactam antibiotics. Pharmacotherapy. 2006; 26( 9): 1320– 1332. - PubMed

LinkOut - more resources