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Meta-Analysis
. 2017 Jun 22;6(6):CD012651.
doi: 10.1002/14651858.CD012651.

Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years

Affiliations
Meta-Analysis

Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years

Emma Mead et al. Cochrane Database Syst Rev. .

Abstract

Background: Child and adolescent overweight and obesity has increased globally, and can be associated with significant short- and long-term health consequences. This is an update of a Cochrane review published first in 2003, and updated previously in 2009. However, the update has now been split into six reviews addressing different childhood obesity treatments at different ages.

Objectives: To assess the effects of diet, physical activity and behavioural interventions (behaviour-changing interventions) for the treatment of overweight or obese children aged 6 to 11 years.

Search methods: We searched CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, LILACS as well as trial registers ClinicalTrials.gov and ICTRP Search Portal. We checked references of studies and systematic reviews. We did not apply any language restrictions. The date of the last search was July 2016 for all databases.

Selection criteria: We selected randomised controlled trials (RCTs) of diet, physical activity, and behavioural interventions (behaviour-changing interventions) for treating overweight or obese children aged 6 to 11 years, with a minimum of six months' follow-up. We excluded interventions that specifically dealt with the treatment of eating disorders or type 2 diabetes, or included participants with a secondary or syndromic cause of obesity.

Data collection and analysis: Two review authors independently screened references, extracted data, assessed risk of bias, and evaluated the quality of the evidence using the GRADE instrument. We contacted study authors for additional information. We carried out meta-analyses according to the statistical guidelines in the Cochrane Handbook for Systematic Reviews of Interventions.

Main results: We included 70 RCTs with a total of 8461 participants randomised to either the intervention or control groups. The number of participants per trial ranged from 16 to 686. Fifty-five trials compared a behaviour-changing intervention with no treatment/usual care control and 15 evaluated the effectiveness of adding an additional component to a behaviour-changing intervention. Sixty-four trials were parallel RCTs, and four were cluster RCTs. Sixty-four trials were multicomponent, two were diet only and four were physical activity only interventions. Ten trials had more than two arms. The overall quality of the evidence was low or very low and 62 trials had a high risk of bias for at least one criterion. Total duration of trials ranged from six months to three years. The median age of participants was 10 years old and the median BMI z score was 2.2.Primary analyses demonstrated that behaviour-changing interventions compared to no treatment/usual care control at longest follow-up reduced BMI, BMI z score and weight. Mean difference (MD) in BMI was -0.53 kg/m2 (95% confidence interval (CI) -0.82 to -0.24); P < 0.00001; 24 trials; 2785 participants; low-quality evidence. MD in BMI z score was -0.06 units (95% CI -0.10 to -0.02); P = 0.001; 37 trials; 4019 participants; low-quality evidence and MD in weight was -1.45 kg (95% CI -1.88 to -1.02); P < 0.00001; 17 trials; 1774 participants; low-quality evidence.Thirty-one trials reported on serious adverse events, with 29 trials reporting zero occurrences RR 0.57 (95% CI 0.17 to 1.93); P = 0.37; 4/2105 participants in the behaviour-changing intervention groups compared with 7/1991 participants in the comparator groups). Few trials reported health-related quality of life or behaviour change outcomes, and none of the analyses demonstrated a substantial difference in these outcomes between intervention and control. In two trials reporting on minutes per day of TV viewing, a small reduction of 6.6 minutes per day (95% CI -12.88 to -0.31), P = 0.04; 2 trials; 55 participants) was found in favour of the intervention. No trials reported on all-cause mortality, morbidity or socioeconomic effects, and few trials reported on participant views; none of which could be meta-analysed.As the meta-analyses revealed substantial heterogeneity, we conducted subgroup analyses to examine the impact of type of comparator, type of intervention, risk of attrition bias, setting, duration of post-intervention follow-up period, parental involvement and baseline BMI z score. No subgroup effects were shown for any of the subgroups on any of the outcomes. Some data indicated that a reduction in BMI immediately post-intervention was no longer evident at follow-up at less than six months, which has to be investigated in further trials.

Authors' conclusions: Multi-component behaviour-changing interventions that incorporate diet, physical activity and behaviour change may be beneficial in achieving small, short-term reductions in BMI, BMI z score and weight in children aged 6 to 11 years. The evidence suggests a very low occurrence of adverse events. The quality of the evidence was low or very low. The heterogeneity observed across all outcomes was not explained by subgrouping. Further research is required of behaviour-changing interventions in lower income countries and in children from different ethnic groups; also on the impact of behaviour-changing interventions on health-related quality of life and comorbidities. The sustainability of reduction in BMI/BMI z score and weight is a key consideration and there is a need for longer-term follow-up and further research on the most appropriate forms of post-intervention maintenance in order to ensure intervention benefits are sustained over the longer term.

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Conflict of interest statement

EM: none known.

TB: none known.

KR: none known.

LA: none known.

VW: none known.

DJ: none known.

JO: none known.

GM: none known.

EC: none known.

CM: none known.

EB: none known.

LA‐K: none known.

LB: is a co‐author on two of the included studies (McCallum 2007; Wake 2009).

MIM: none known.

Disclaimer: Alessandro Demaio is currently a staff member of the World Health Organization. The author alone is responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the World Health Organization.

LE: is seconded to Public Health England part‐time as a specialist obesity advisor. The author received funding from WHO to complete this review. Louisa Ells also has a part time secondment to Public Health England, but undertook this review within her role at Teesside University.

Figures

1
1
Trial flow diagram
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies (blank cells indicate that the particular outcome was not investigated in some studies)
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study (blank cells indicate that the study did not report that particular outcome)
4
4
Forest plot of comparison: 1 Lifestyle intervention versus no treatment/usual care, outcome: 1.1 Change in BMI (all trials) (kg/m²)
5
5
Forest plot of comparison: 1 Lifestyle intervention versus no treatment/usual care, outcome: 1.2 Change in BMI z score (all trials)
6
6
Forest plot of comparison: 1 Lifestyle intervention versus no treatment/usual care, outcome: 1.3 Change in weight (all trials)
1.1
1.1. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 1 Change in BMI (all trials).
1.2
1.2. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 2 Change in BMI z score (all trials).
1.3
1.3. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 3 Change in weight (all trials).
1.4
1.4. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 4 Serious adverse events.
1.5
1.5. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 5 Health‐related quality of life (parent‐report measures).
1.6
1.6. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 6 Health‐related quality of life (child‐report measures).
1.7
1.7. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 7 Self‐esteem (Harter global score).
1.8
1.8. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 8 Waist circumference.
1.9
1.9. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 9 Overweight.
1.10
1.10. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 10 Body fat.
1.11
1.11. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 11 Diet.
1.12
1.12. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 12 Television viewing.
1.13
1.13. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 13 Physical activity (accelerometer MVPA).
1.14
1.14. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 14 Change in BMI ‐ type of control.
1.15
1.15. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 15 Change in BMI z score ‐ type of control.
1.16
1.16. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 16 Change in weight ‐ type of control.
1.17
1.17. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 17 Change in BMI ‐ type of intervention.
1.18
1.18. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 18 Change in BMI z score ‐ type of intervention.
1.19
1.19. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 19 Change in weight ‐ type of intervention.
1.20
1.20. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 20 Change in BMI ‐ attrition bias.
1.21
1.21. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 21 Change in BMI z score ‐ attrition bias.
1.22
1.22. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 22 Change in weight ‐ attrition bias.
1.23
1.23. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 23 Change in weight ‐ setting.
1.24
1.24. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 24 Change in BMI z score ‐ setting.
1.25
1.25. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 25 Change in BMI ‐ setting.
1.26
1.26. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 26 Change in BMI ‐ post‐intervention follow‐up.
1.27
1.27. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 27 Change in BMI z score ‐ post‐intervention follow‐up.
1.28
1.28. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 28 Change in weight ‐ post‐intervention follow‐up.
1.29
1.29. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 29 Change in BMI ‐ type of parental involvement.
1.30
1.30. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 30 Change in BMI z score ‐ type of parental involvement.
1.31
1.31. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 31 Change in weight ‐ type of parental involvement.
1.32
1.32. Analysis
Comparison 1 Behaviour‐changing interventions versus no treatment/usual care, Outcome 32 Change in BMI z score ‐ baseline BMI z score.
2.1
2.1. Analysis
Comparison 2 Behaviour‐changing interventions plus component versus behaviour‐changing intervention without component, Outcome 1 Change in BMI.
2.2
2.2. Analysis
Comparison 2 Behaviour‐changing interventions plus component versus behaviour‐changing intervention without component, Outcome 2 Change in BMI z score.
2.3
2.3. Analysis
Comparison 2 Behaviour‐changing interventions plus component versus behaviour‐changing intervention without component, Outcome 3 Change in weight.
3.1
3.1. Analysis
Comparison 3 Cluster RCTs versus comparator, Outcome 1 Change in BMI.
4.1
4.1. Analysis
Comparison 4 Maintenance intervention versus no treatment/usual care, Outcome 1 Change in BMI z score.

References

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Diaz 2010 {published data only}
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Eddy Ives 2012 {published data only}
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Epstein 1984a {published data only}
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Epstein 1985a {published data only}
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Epstein 1985b {published data only}
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Epstein 2001 {published data only}
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Hughes 2008 {published data only}
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Kalarchian 2009 {published data only}
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Lison 2012 {published data only}
    1. Lison JF, Real‐Montes JM, Torro I, Arguisuelas MD, Alvarez‐Pitti J, Martinez‐Gramage J, et al. Exercise intervention in childhood obesity: a randomized controlled trial comparing hospital‐versus home‐based groups. Academic Pediatrics 2012;12(4):319‐25. - PubMed
    1. NCT01503281. Effects of group vs. home‐based combined exercise‐diet program in childhood obesity: a randomised controlled trial. clinicaltrials.gov/ct2/show/NCT01503281 (last accessed 6 December 2016).
Lochrie 2013 {published data only}
    1. Lochrie AS, Wysocki T, Hossain J, Milkes A, Antal H, Buckloh L, et al. The effects of a family‐based intervention (FBI) for overweight/obese children on health and psychological functioning. Psychology 2013;1(2):159‐70.
    1. NCT01146314. A family based intervention to reduce the risk of type 2 diabetes in children (FBI). clinicaltrials.gov/ct2/show/NCT01146314 (last accessed 6 December 2016).
Looney 2014 {published data only}
    1. Looney SM, Raynor HA. Examining the effect of three low‐intensity pediatric obesity interventions a pilot randomized controlled trial. Clinical Pediatrics 2014;53(14):1367‐74. - PubMed
    1. NCT01358448. A pilot study of the efficacy and program cost‐effectiveness of prevention plus for childhood obesity. clinicaltrials.gov/ct2/show/NCT01358448 (last accessed 6 December 2016).
Maddison 2011 {published data only}
    1. ACTRN12607000632493. Electronic games to aid motivation to exercise (eGAME). www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=82468 (last accessed 6 December 2016).
    1. Foley L, Jiang Y, Ni Mhurchu C, Jull A, Prapavessis H, Rodgers A, et al. The effect of active video games by ethnicity, sex and fitness: subgroup analysis from a randomised controlled trial. International Journal of Behavioral Nutrition & Physical Activity 2014;11(1):46. - PMC - PubMed
    1. Maddison R, Foley L, Jiang Y, Ni Mhurchu C, Jull A, Rodgers A, et al. Electronic games to aid motivation to exercise: a randomized controlled trial. Obesity Reviews 2010;11:50.
    1. Maddison R, Foley L, Mhurchu CN, Jull A, Jiang Y, Prapavessis H, et al. Feasibility, design and conduct of a pragmatic randomized controlled trial to reduce overweight and obesity in children: the electronic games to aid motivation to exercise (eGAME) study. BMC Public Health 2009;9:146. - PMC - PubMed
    1. Maddison R, Foley L, Ni Mhurchu C, Jiang Y, Jull A, Prapavessis H, et al. Effects of active video games on body composition: a randomized controlled trial. American Journal of Clinical Nutrition 2011;94(1):156‐63. - PubMed
Maddison 2014 {published data only}
    1. ACTRN12611000164998. Screen‐time weight‐loss intervention targeting children at home. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=336430 (last accessed 6 December 2016).
    1. Maddison R, Marsh S, Foley L, Epstein LH, Olds T, Dewes O, et al. Screen‐Time Weight‐loss Intervention Targeting Children at Home (SWITCH): a randomized controlled trial. International Journal of Behavioral Nutrition and Physical Activity 2014;11:111. - PMC - PubMed
    1. Maddison R, Mhurchu CN, Foley L, Epstein L, Jiang Y, Tsai M, et al. Screen‐time weight‐loss intervention targeting children at home (SWITCH): a randomized controlled trial study protocol. BMC Public Health 2011;11:524. - PMC - PubMed
Markert 2014 {published data only}
    1. DRKS00000803. T.A.F.F. ‐ Telephone‐based adiposity prevention for families. apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00000803 (last accessed 6 December 2016).
    1. Markert J, Alff F, Zschaler S, Gausche R, Kiess W, Blüher S. Prevention of childhood obesity: recruiting strategies via local paediatricians and study protocol for a telephone‐based counselling programme. Obesity Research & Clinical Practice 2013;7(6):e476–86. - PubMed
    1. Markert J, Herget S, Petroff D, Gausche R, Grimm A, Kiess W, et al. Telephone‐based adiposity prevention for families with overweight children (T.A.F.F.‐Study): one year outcome of a randomized, controlled trial. International Journal of Environmental Research & Public Health 2014;11(10):10327‐44. - PMC - PubMed
McCallum 2007 {published data only}
    1. Gibbons K, McCallum Z, Wake M. A primary care intervention for childhood obesity: six‐month results from LEAP (Live, Eat And Play), a randomised controlled trial. International Journal of Obesity 2004;28:S194. - PubMed
    1. Gunn J, McCallum Z, Sanci L, Gerner B, Harris C, Wake M. What do GPs get out of participating in research? ‐ experience of the LEAP trial. Australian Family Physician 2008;37(5):372‐5. - PubMed
    1. ISRCTN45068927. Randomised controlled trial of a brief GP intervention to reduce overweight in Victorian primary school children (LEAP). www.isrctn.com/ISRCTN45068927 (last accessed 6 December 2016).
    1. McCallum Z, Wake M. A primary care intervention for childhood overweight/obesity (leap): methodology of a randomised controlled trial. Journal of Paediatrics and Child Health 2003;39(6):A16.
    1. McCallum Z, Wake M, Baur L. The Leap (live, eat and play) trial: results of a randomized controlled trial of a primary care intervention for childhood overweight/mild obesity. Obesity Research 2004;12:A15‐6. - PubMed
Mirza 2013 {published data only}
    1. Mirza NM, Palmer MG, Sinclair KB, McCarter R, He J, Ebbeling CB, et al. Effects of a low glycemic load or a low‐fat dietary intervention on body weight in obese Hispanic American children and adolescents: a randomized controlled trial. American Journal of Clinical Nutrition 2013;97(2):276‐85. - PMC - PubMed
    1. NCT01068197. Low glycemic load diets in Latino children at risk for type 2 diabetes (COOL Kids). clinicaltrials.gov/ct2/show/NCT01068197 (last accessed 6 December 2016).
NCT02436330 {unpublished data only}
    1. NCT02436330. Exergaming for health: impact of a community‐based active video gaming curriculum in pediatric weight management. clinicaltrials.gov/ct2/show/NCT02436330 (last accessed 6 December 2016).
Nemet 2005 {published data only}
    1. Nemet D, Barkan S, Epstein Y, Friedland O, Kowen G, Eliakim A. Short‐ and long‐term beneficial effects of a combined dietary‐behavioral‐physical activity intervention for the treatment of childhood obesity. Pediatrics 2005;115(4):e443‐9. - PubMed
Nova 2001 {published data only}
    1. Nova A, Russo A, Sala E. Long‐term management of obesity in paediatric office practice: experimental evaluation of two different types of intervention. Ambulatory Child Health 2001;7(3/4):239‐48.
Nowicka 2009 {published data only}
    1. Nowicka P, Lanke J, Pietrobelli A, Apitzsch E, Flodmark CE. Sports camp with six months of support from a local sports club as a treatment for childhood obesity. Scandinavian Journal of Public Health, 2009;37(8):793‐800. - PubMed
O'Connor 2013 {published data only}
    1. Ledoux T, Hilmers A, Watson K, Baranowski T, O'Connor TM. Development and feasibility of an objective measure of patient‐centered communication fidelity in a pediatric obesity intervention. Journal of Nutrition Education and Behavior 2013;45(4):349‐54. - PubMed
    1. NCT01195012. Pilot RCT of an obesity intervention for primary care pediatrics: Helping HAND. clinicaltrials.gov/ct2/show/NCT01195012 (last accessed 6 December 2016).
    1. O'Connor TM, Hilmers A, Watson K, Baranowski T, Giardino AP. Feasibility of an obesity intervention for paediatric primary care targeting parenting and children: Helping HAND. Child: Care, Health & Development 2013;39(1):141‐9. - PubMed
Reinehr 2010 {published data only}
    1. Finne E, Reinehr T, Schaefer A, Winkel K, Kolip P. Changes in self‐reported and parent‐reported health‐related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12‐month follow‐up study. Health and Quality of Life Outcomes 2013;11:1. - PMC - PubMed
    1. Finne E, Reinehr T, Schaefer A, Winkel K, Kolip P. Overweight children and adolescents – is there a subjective need for treatment?. International Journal of Public Health 2009;54(2):112‐6. - PubMed
    1. NCT00422916. Treatment of overweight children and adolescents. clinicaltrials.gov/ct2/show/NCT00422916 (last accessed 6 December 2016).
    1. Reinehr T, Schaefer A, Winkel K, Finne E, Toschke AM, Kolip P. An effective lifestyle intervention in overweight children: findings from a randomized controlled trial on "Obeldicks light". Clinical Nutrition 2010;29(3):331‐6. - PubMed
    1. Schaefer A, Winkel K, Finne E, Kolip P, Reinehr, T. An effective lifestyle intervention in overweight children: one‐year follow‐up after the randomized controlled trial on "Obeldicks light". Clinical Nutrition 2011;30(5):629‐33. - PubMed
Rodearmel 2007 {published data only}
    1. Holm KE, Wyatt HR, Murphy JR, Hill JO, Ogden LG. Parental influence on child change in physical activity during a family‐based intervention for child weight gain prevention. Journal of Physical Activity & Health 2012;9(5):661–9. - PMC - PubMed
    1. Rodearmel SJ, Wyatt HR, Stroebele N, Smith SM, Ogden LG, Hill JO. Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: the America on the Move family study. Pediatrics 2007;120(4):e869‐79. - PubMed
Sacher 2010 {published data only}
    1. ISRCTN30238779. Improving health outcomes in obese children: a randomised controlled trial of the MEND programme. www.isrctn.com/ISRCTN30238779 (last accessed 6 December 2016).
    1. Sacher PM, Kolotourou M, Chadwick PM, Cole TJ, Lawson MS, Lucas A, et al. Randomized controlled trial of the MEND program: a family‐based community intervention for childhood obesity. Obesity 2010;18(Suppl 1):S62‐8. - PubMed
Saelens 2013 {published data only}
    1. NCT00746629. Familial overweight: comparing use of strategies (FOCUS). clinicaltrials.gov/ct2/show/NCT00746629 (last accessed 6 December 2016).
    1. Saelens BE, Lozano P, Scholz K. A randomized clinical trial comparing delivery of behavioral pediatric obesity treatment using standard and enhanced motivational approaches. Journal of Pediatric Psychology 2013;38(9):954‐64. - PMC - PubMed
Satoh 2007 {published data only}
    1. Satoh A, Menzawa K, Lee S, Hatakeyama A, Sasaki H. Dietary guidance for obese children and their families using a model nutritional balance chart. Japan Journal of Nursing Science 2007;4(2):95‐102.
Schwingshandl 1999 {published data only}
    1. Schwingshandl J, Sudi K, Eibl B, Wallner S, Brokenstein M. Effect of an individualised training programme during weight reduction on body composition: a randomised trial. Archives of Diseases in Childhood 1999;81(5):426‐8. - PMC - PubMed
Serra‐Paya 2015 {published data only}
    1. NCT01878994. Evaluation of a family intervention program for the management of overweight or obese children (NEREU). clinicaltrials.gov/ct2/show/NCT01878994 (last accessed 6 December 2016).
    1. Serra‐Paya N, Ensenyat A, Castro‐Vinuales I, Real J, Sinfreu‐Bergues X, Zapata A, et al. Effectiveness of a multi‐component intervention for overweight and obese children (Nereu Program): a randomized controlled trial. PLoS One 2015;10(12):e0144502. - PMC - PubMed
    1. Serra‐Paya N, Ensenyat A, Real J, Castro‐Vinuales I, Zapata A, Galindo G, et al. Evaluation of a family intervention programme for the treatment of overweight and obese children (Nereu Programme): a randomized clinical trial study protocol. BMC Public Health 2013;13:1000. - PMC - PubMed
Siwik 2013 {published data only}
    1. NCT01674920. CHOICES: family physicians treat overweight children. clinicaltrials.gov/ct2/show/NCT01674920 (last accessed 6 December 2016).
    1. Siwik V, Kutob R, Ritenbaugh C, Cruz L, Senf J, Aickin M, et al. Intervention in overweight children improves body mass index (BMI) and physical activity. Journal of the American Board of Family Medicine 2013;26(2):126‐37. - PMC - PubMed
Taveras 2015 {published data only}
    1. NCT01537510. Study of technology to accelerate research (STAR). clinicaltrials.gov/ct2/show/NCT01537510 (last accessed 6 December 2016).
    1. Taveras EM, Marshall R, Horan CM, Gillman MW, Hacker K, Kleinman KP, et al. Rationale and design of the STAR randomized controlled trial to accelerate adoption of childhood obesity comparative effectiveness research. Contemporary Clinical Trials 2013;34(1):101‐8. - PubMed
    1. Taveras EM, Marshall R, Kleinman KP, Gillman MW, Hacker K, Horan CM, et al. Comparative effectiveness of childhood obesity interventions in pediatric primary care: a cluster‐randomized clinical trial. JAMA pediatrics 2015;169(6):535‐42. - PubMed
Taylor 2015 {published data only}
    1. ACTRN12609000749202. Screening, feedback and treatment in overweight 4‐8 year old children: the MInT study. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=308336 (last accessed 6 December 2016).
    1. Dawson AM, Brown DA, Cox A, Williams SM, Treacy L, Haszard J, et al. Using motivational interviewing for weight feedback to parents of young children. Journal of Paediatrics and Child Health 2014;50(6):461‐70. - PubMed
    1. Dawson AM, Taylor RW, Williams SM, Taylor BJ, Brown DA. Do parents recall and understand children's weight status information after BMI screening?. BMJ Open 2014;4(7):e004481. - PMC - PubMed
    1. Haszard JJ, Williams SM, Dawson AM, Skidmore PML, Taylor RW. Factor analysis of the comprehensive feeding practices questionnaire in a large sample of children. Appetite 2013;62:110‐8. - PubMed
    1. Taylor RW, Brown D, Dawson AM, Haszard J, Cox A, Rose EA, et al. Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4‐8 year old children: design of the MInT study. BMC Public Health 2010;10:271. - PMC - PubMed
Vann 2013 {published data only}
    1. Vann LH, Stanford FC, Durkin MW, Hanna A, Knight LM, Stallworth JR. "Moving and losing": a pilot study incorporating physical activity to decrease obesity in the pediatric population. Journal of the South Carolina Medical Association 2013;109(4):116‐20. - PubMed
Wafa 2011 {published data only}
    1. Hamzaid H, Talib RA, Azizi NH, Maamor N, Reilly JJ, Wafa SW. Quality of life of obese children in Malaysia. International Journal of Pediatric Obesity 2011;6(5‐6):450‐4. - PubMed
    1. ISRCTN14241825. Malaysian childhood obesity treatment trial (MASCOT). www.isrctn.com/ISRCTN14241825 (last accessed 6 December 2016).
    1. Sharifah WW, Nur HH, Ruzita AT, Roslee R, Reilly JJ. The Malaysian Childhood Obesity Treatment Trial (MASCOT). Malaysian Journal of Nutrition 2011;17(2):229‐36. - PubMed
    1. Wafa SW, Ruzita AT, Nur Hana H, Roslee R, Ng LO, Ayiesah R, et al. Family‐focused weight management programme for childhood obesity in Malaysia: randomised controlled trial. Obesity Reviews 2010;11:85‐6.
    1. Wafa SW, Talib RA, Hamzaid NH, McColl JH, Rajikan R, Ng LO, et al. Randomized controlled trial of a good practice approach to treatment of childhood obesity in Malaysia: Malaysian Childhood Obesity Treatment Trial (MASCOT). International Journal of Pediatric Obesity 2011;6(2‐2):e62‐9. - PubMed
Wake 2009 {published data only}
    1. ISRCTN52511065. Randomised controlled trial of a brief GP intervention to reduce overweight in Victorian primary school children ‐ live, eat and play (LEAP 2). www.isrctn.com/ISRCTN52511065 (last accessed 6 December 2016).
    1. Wake M, Baur LA, Gerner B, Gibbons K, Gold L, Gunn J, et al. Outcomes and costs of primary care surveillance and intervention for overweight or obese children: the LEAP 2 randomised controlled trial. BMJ 2009;339:b3308. - PMC - PubMed
Wake 2013 {published data only}
    1. ACTRN12608000055303. Better outcomes for obese children in general practice: randomized controlled trial of a new shared‐care model vs usual care. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=82549 (last accessed 6 December 2016).
    1. Wake M, Lycett K, Clifford SA, Sabin MA, Gunn J, Gibbons K, et al. Shared care obesity management in 3‐10 year old children: 12 month outcomes of HopSCOTCH randomised trial. BMJ 2013;346:f3092. - PMC - PubMed
    1. Wake M, Lycett K, Sabin MA, Gunn J, Gibbons K, Hutton C, et al. A shared‐care model of obesity treatment for 3‐10 year old children: protocol for the HopSCOTCH randomised controlled trial. BMC Pediatrics 2012;12:39. - PMC - PubMed
Waling 2012 {published data only}
    1. Backlund C, Sundelin G, Larsson C. Effect of a 1‐year lifestyle intervention on physical activity in overweight and obese children. Advances in Physiotherapy 2011;13(3):87‐96.
    1. Backlund C, Sundelin G, Larsson C. Effects of a 2‐year lifestyle intervention on physical activity in overweight and obese children. Advances in Physiotherapy 2011;13(3):97‐109.
    1. NCT01012206. Overweighed children's health ‐ studies of the effect of lifestyle and food habits (SELFH). clinicaltrials.gov/ct2/show/NCT01012206 (last accessed 6 December 2016).
    1. Waling M, Backlund C, Lind T, Larsson C. Effects on metabolic health after a 1‐year‐lifestyle intervention in overweight and obese children: a randomized controlled trial. Journal of Nutrition and Metabolism 2012;2012(913965):1‐10. - PMC - PubMed
    1. Waling M, Lind T, Hernell O, Larsson C. A one‐year intervention has modest effects on energy and macronutrient intakes of overweight and obese Swedish children. Journal of Nutrition 2010;140(10):1793‐8. - PubMed
Warschburger 2016 {published data only}
    1. ISRCTN24655766. Empowering parents of obese children: development and controlled evaluation of an obesity‐specific parenting skills training. www.isrctn.com/ISRCTN24655766 (last accessed 6 December 2016).
    1. Warschburger P, Kroeller K, Haerting J, Unverzagt S, Egmond‐Fröhlich A. Empowering Parents of Obese Children (EPOC): a randomized controlled trial on additional long‐term weight effects of parent training. Appetite 2016;103:148‐56. - PubMed
    1. Warschburger P, Kroller K, Unverzagt S, Haerting J. What is the parents' part in long‐term weight management of their obese child? Results from the EPOC study. Obesity Facts 2013;6:230.
Weigel 2008 {published data only}
    1. Weigel C, Kokocinski K, Lederer P, Dotsch J, Rascher W, Knerr I. Childhood obesity: concept, feasibility, and interim results of a local group‐based, long‐term treatment program. Journal of Nutrition Education & Behavior 2008;40(6):369‐73. - PubMed
Weintraub 2008 {published data only}
    1. NCT00186173. Sports to prevent obesity: feasibility and pilot RCT. clinicaltrials.gov/ct2/show/NCT00186173 (last accessed 6 December 2016).
    1. Weintraub DL, Tirumalai EC, Haydel KF, Fujimoto M, Fulton JE, Robinson TN. Team sports for overweight children: the Stanford Sports to Prevent Obesity Randomized Trial (SPORT). Archives of Pediatrics & Adolescent Medicine 2008;162(3):232‐7. - PubMed
Wilfley 2007 {published data only}
    1. Goldschmidt AB, Stein RI, Saelens BE, Theim KR, Epstein LH, Wilfley DE. Importance of early weight change in a pediatric weight management trial. Pediatrics 2011;128(1):e33‐9. - PMC - PubMed
    1. NCT00301197. Childhood obesity treatment: a maintenance approach. clinicaltrials.gov/ct2/show/NCT00301197 (last accessed 6 December 2016).
    1. Theim KR, Sinton MM, Goldschmidt AB, Buren DJ, Doyle AC, Saelens BE, et al. Adherence to behavioral targets and treatment attendance during a pediatric weight control trial. Obesity 2013;21(2):394‐7. - PMC - PubMed
    1. Wilfley DE, Stein RI, Saelens BE, Mockus DS, Matt GE, Hayden‐Wade HA, et al. Efficacy of maintenance treatment approaches for childhood overweight: a randomized controlled trial. JAMA 2007;298(14):1661‐73. - PubMed
Woo 2004 {published data only}
    1. Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, et al. Effects of diet and exercise on obesity‐related vascular dysfunction in children. Circulation 2004;109(16):1981‐6. - PubMed
Wright 2012 {published data only}
    1. Wright K, Giger JN, Norris K, Suro Z. Impact of a nurse‐directed, coordinated school health program to enhance physical activity behaviors and reduce body mass index among minority children: a parallel‐group, randomized control trial. International Journal of Nursing Studies 2013;50(6):727‐37. - PMC - PubMed
    1. Wright K, Norris K, Newman Giger J, Suro Z. Improving healthy dietary behaviors, nutrition knowledge, and self‐efficacy among underserved school children with parent and community involvement. Childhood Obesity 2012;8(4):347‐56. - PubMed
    1. Wright K, Suro Z. Using community‐academic partnerships and a comprehensive school‐based program to decrease health disparities in activity in school‐aged children. Journal of Prevention & Intervention in the Community 2014;42(2):125‐39. - PubMed

References to studies excluded from this review

Adam 2009 {published data only}
    1. Adam S, Westenhofer J, Rudolphi B, Kraaibeek HK. Effects of a combined inpatient‐outpatient treatment of obese children and adolescents. Obesity Facts 2009;2:286‐93. - PMC - PubMed
Albala 2008 {published data only}
    1. Albala C, Ebbeling CB, Cifuentes M, Lera L, Bustos N, Ludwig DS. Effects of replacing the habitual consumption of sugar‐sweetened beverages with milk in Chilean children. American Journal of Clinical Nutrition 2008;88(3):605‐11. - PMC - PubMed
Alberga 2013 {published data only}
    1. Alberga AS, Farnesi BC, Lafleche A, Legault L, Komorowski J. The effects of resistance exercise training on body composition and strength in obese prepubertal children. Physician & Sports medicine 2013;41(3):103‐9. - PubMed
Alexander 2014 {published data only}
    1. Alexander AG, Grant WL, Pedrino KJ, Lyons PE. A prospective multifactorial intervention on subpopulations of predominately Hispanic children at high risk for obesity. Obesity 2014; Vol. 22, issue 1:249‐53. - PubMed
Amini 2016 {published data only}
    1. Amini M, Djazayery A, Majdzadeh R, Taghdisi MH, Sadrzadeh‐Yeganeh H, Abdollahi Z, et al. A school‐based intervention to reduce excess weight in overweight and obese primary school students. Biological Research for Nursing 2016;29:29. - PubMed
Andre 2015 {published data only}
    1. Andre N, Beguier S. Using motivational interviewing as a supplement to physical activity program in obese adolescents: a RCT study. Eating and Weight Disorders 2015; Vol. 20, issue 4:519‐23. - PubMed
Astrup 2013 {published data only}
    1. Astrup A, Damsgaard CT, Papadaki A, Jensen SM, Dalskov SM, Hlavaty P, et al. 1 The use of an ad libitum higher‐protein, low‐glycemic index diet in overweight children: the Diogenes Study. FASEB Journal 2013;27:249.8.
Bachman 2010 {published data only}
    1. Bachman J, Raynor H. Parent and child dietary change during a family‐based behavioral childhood obesity intervention. Obesity 2010;18:S117.
Baker 2012 {published data only}
    1. Baker J, Saunders K. Fitter, healthier, happier families: a partnership to treat childhood obesity in the West Midlands. Public Health 2012;126(4):332‐4. - PubMed
Ball 2012 {published data only}
    1. Ball GD, Ambler KA, Keaschuk RA, Rosychuk RJ, Holt NL, Spence JC, et al. Parents as agents of change (PAC) in pediatric weight management: the protocol for the PAC randomized clinical trial. BMC Pediatrics 2012;12:114. - PMC - PubMed
Banks 2011 {published data only}
    1. Banks J, Shield JP, Sharp D. Barriers engaging families and GPs in childhood weight management strategies. British Journal of General Practice 2011;61(589):e492‐7. - PMC - PubMed
Banks 2012a {published data only}
    1. Banks J, Sharp DJ, Hunt LP, Shield JP. Evaluating the transferability of a hospital‐based childhood obesity clinic to primary care: a randomised controlled trial. British Journal of General Practice 2012;62(594):e6‐12. - PMC - PubMed
Banks 2012b {published data only}
    1. Banks J, Williams J, Cumberlidge T, Cimonetti T, Sharp DJ, Shield JP. Is healthy eating for obese children necessarily more costly for families?. British Journal of General Practice 2012;62(594):e1‐5. - PMC - PubMed
Banks 2014 {published data only}
    1. Banks J, Cramer H, Sharp DJ, Shield JP, Turner KM. Identifying families' reasons for engaging or not engaging with childhood obesity services: a qualitative study. Journal of Child Health Care 2014;18(2):101‐10. - PubMed
Banos 2009 {published data only}
    1. Banos RM, Cebolla A, Zaragoza I, Botella C, Alcaniz M. Electronic PDA dietary and physical activity registers in a weight loss treatment program for children: a description of the ETIOBE personal digital assistant program. Journal of Cybertherapy and Rehabilitation 2009;2:235‐41.
Baranowski 2011 {published data only}
    1. Baranowski T, Baranowski J, Thompson D, Buday R, Jago R, Griffith MJ, et al. Video game play, child diet, and physical activity behavior change a randomized clinical trial. American Journal of Preventive Medicine 2011;40(1):33‐8. - PMC - PubMed
Barbeau 2007 {published data only}
    1. Barbeau P, Johnson MH, Howe CA, Allison J, Davis CL, Gutin B, et al. Ten months of exercise improves general and visceral adiposity, bone, and fitness in black girls. Obesity 2007;15(8):2077‐85. - PubMed
Bau 2016 {published data only}
    1. Bau AM, Ernert A, Krude H, Wiegand S. Hormonal regulatory mechanisms in obese children and adolescents after previous weight reduction with a lifestyle intervention: maintain ‐ paediatric part ‐ a RCT from 2009‐15. BMC Obesity 2016;3:29. - PMC - PubMed
Bauer 2010 {published data only}
    1. Bauer S, Niet J, Timman R, Kordy H. Enhancement of care through self‐monitoring and tailored feedback via text messaging and their use in the treatment of childhood overweight. Patient Education and Counseling 2010;79(3):315‐9. - PubMed
Bayat 2014 {published data only}
    1. Bayat E, Rahimian Boogar I, Talepasand S, Yousefi Chaigan P. The effectiveness of family‐based cognitive behavioral therapy in weight reduction among children with obesity. Iranian Journal of Endocrinology and Metabolism 2014;16:254‐61.
Bean 2012 {published data only}
    1. Bean MK, Wilson DB, Thornton LM, Kelly N, Mazzeo SE. Dietary intake in a randomized‐controlled pilot of NOURISH: a parent intervention for overweight children. Preventive Medicine 2012;55(3):224‐7. - PMC - PubMed
Bean 2014 {published data only}
    1. Bean MK, Jeffers AJ, Tully CB, Thornton LM, Mazzeo SE. Motivational interviewing with parents of overweight children: study design and methods for the NOURISH + MI study. Contemporary Clinical Trials 2014;37(2):312‐21. - PMC - PubMed
Benestad 2014 {published data only}
    1. Benestad B, Lekhal S, Hertel JK, Odegard R, Hjelmesaeth J. Long‐term effectiveness of two family based life style intervention programs on childhood obesity. A 2‐years randomized controlled pragmatic trial. Obesity Facts 2014;7:131.
Benson 2008 {published data only}
    1. Benson AC, Torode ME, Fiatarone Singh MA. The effect of high‐intensity progressive resistance training on adiposity in children: a randomized controlled trial. International Journal of Obesity 2008;32(6):1016‐27. - PubMed
Bernstein 2015 {published data only}
    1. Bernstein HM. An ecological systems approach to pediatric weight management: a psychoeducational group manual for caregivers [Dissertation]. Vol. 75, Available from gradworks.umi.com/36/30/3630291.html, 2015.
Best 2016 {published data only}
    1. Best JR, Goldschmidt AB, Mockus‐Valenzuela DS, Stein RI, Epstein LH, Wilfley DE. Shared weight and dietary changes in parent‐child dyads following family‐based obesity treatment. Health Psychology 2016;35(1):92‐5. - PMC - PubMed
Bloom 2013 {published data only}
    1. Bloom T, Sharpe L, Mullan B, Zucker N. A pilot evaluation of appetite‐awareness training in the treatment of childhood overweight and obesity: a preliminary investigation. International Journal of Eating Disorders 2013;46(1):47‐51. - PubMed
Bocca 2014 {published data only}
    1. Bocca G, Corpeleijn E, Heuvel ER, Stolk RP, Sauer PJ. Three‐year follow‐up of 3‐year‐old to 5‐year‐old children after participation in a multidisciplinary or a usual‐care obesity treatment program. Clinical Nutrition 2014;33(6):1095‐100. - PubMed
Bohnert 2013 {published data only}
    1. Bohnert AM, Ward AK. Making a difference: evaluating the Girls in the Game (GIG) after‐school program. The Journal of Early Adolescence 2013;33(1):104‐30.
Boutelle 2011 {published data only}
    1. Boutelle KN, Zucker NL, Peterson CB, Rydell SA, Cafri G, Harnack L. Two novel treatments to reduce overeating in overweight children: a randomized controlled trial. Journal of Consulting & Clinical Psychology 2011;79(6):759‐71. - PMC - PubMed
Boutelle 2013 {published data only}
    1. Boutelle KN, Norman GJ, Rock CL, Rhee KE, Crow SJ. Guided self‐help for the treatment of pediatric obesity. Pediatrics 2013;131:e1435‐42. - PMC - PubMed
Braden 2014 {published data only}
    1. Braden A, Rhee K, Peterson CB, Rydell SA, Zucker N, Boutelle K. Associations between child emotional eating and general parenting style, feeding practices, and parent psychopathology. Appetite 2014;80:35‐40. - PubMed
Braet 1997a {published data only}
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Braet 1997b {published data only}
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Braet 2000 {published data only}
    1. Braet C, Winckel M. Long‐term follow‐up of a cognitive behavioral treatment program for obese children. Behavior Therapy 2000;31:55‐74.
Buhari 2014 {published data only}
    1. Buhari SSS, Talib RA, Koon PB. The HEBAT! program: an obesity prevention exploratory cluster randomized controlled trial. Obesity Reviews 2014;15:153.
Burrows 2008 {published data only}
    1. Burrows T, Warren JM, Baur LA, Collins CE. Impact of a child obesity intervention on dietary intake and behaviors. International Journal of Obesity 2008;32:1481‐8. - PubMed
Burrows 2010a {published data only}
    1. Burrows T, Berthton B, Garg M, Collins C. A novel approach to validating dietary change in children participating in the HIKCUPS (Hunter Illawarra Kids Challenge Using Parent Support) obesity intervention. Obesity Reviews 2010;11:374.
Burrows 2010b {published data only}
    1. Burrows T, Warren JM, Collins CE. The impact of a child obesity treatment intervention on parent child‐feeding practices. International Journal of Pediatric Obesity 2010;5:43‐50. - PubMed
Burrows 2011 {published data only}
    1. Burrows T, Janet WM, Collins CE. Long‐term changes in food consumption trends in overweight children in the HIKCUPS intervention. Journal of Pediatric Gastroenterology & Nutrition 2011;53:543‐7. - PubMed
Bush 2007 {published data only}
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Bustos 1997 {published data only}
    1. Bustos LG, Moreno MF, Calderin MMA, Martinez QJJ, Diaz ME, Arana CC. Comparative study of medical advice and cognitive‐behavioral group therapy in the treatment of child‐adolescent obesity. Anales Espanoles de Pediatria 1997;47:135‐43. - PubMed
Caballero 2003a {published data only}
    1. Caballero B, Clay T, Davis SM, Ethelbah B, Rock BH, Lohman T, et al. Pathways: a school‐based, randomized controlled trial for the prevention of obesity in American Indian schoolchildren. American Journal of Clinical Nutrition 2003;78:1030‐8. - PMC - PubMed
Caballero 2003b {published data only}
    1. Caballero B, Himes JH, Lohman T, Davis SM, Stevens J, Evans M, et al. Body composition and overweight prevalence in 1704 schoolchildren from 7 American Indian communities. American Journal of Clinical Nutrition 2003;78:308‐12. - PMC - PubMed
Canas 2012a {published data only}
    1. Canas JA, Damaso L, Altomare A, Killen K, Hossain J, Balagopal PB. Insulin resistance and adiposity in relation to serum beta‐carotene levels. Journal of Pediatrics 2012;161:58‐64.e1‐2. - PubMed
Canas 2012b {published data only}
    1. Canas JA, Damaso L, Mann KJ, Sweeten S, Balagopa P. Fatty acid binding proteins (FABP4 and FABP5), beta‐carotene and insulin resistance (IR): a 6‐month double blind placebo‐controlled study on the effect of a fruit and vegetable juice concentrate (FVJC) in boys. Endocrine Reviews 2012;33 (3 Meeting Abstracts):No pagination.
Canas 2014 {published data only}
    1. Canas J, Lochrie A, McGowan AG, Schettino C, Hossain J, Balagopal P. Effect of a 2‐week intense life‐style intervention followed by 6‐month carotenoid supplementation on fat depots, aditonectin and palmitoleate: a 6‐month double blind placebo‐controlled pilot study in obese children. FASEB Journal 2014;1:645.6.
Carrel 2005 {published data only}
    1. Carrel AL, Clark RR, Peterson SE, Nemeth BA, Sullivan J, Allen DB. Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school‐based exercise program: a randomized, controlled study. Archives of Pediatrics & Adolescent Medicine 2005;159:963‐8. - PubMed
Carrel 2007 {published data only}
    1. Carrel AL, Clark RR, Peterson S, Eickhoff J, Allen DB. School‐based fitness changes are lost during the summer vacation. Archives of Pediatrics & Adolescent Medicine 2007;161:561‐4. - PubMed
Cash 2009 {published data only}
    1. Cash AJ. Evaluation of a multi‐faceted intervention to prevent obesity in elementary school children. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2009; Vol. 69:7446.
Catenacci 2014 {published data only}
    1. Catenacci VA, Barrett C, Odgen L, Browning R, Schaefer CA, Hill J, et al. Changes in physical activity and sedentary behavior in a randomized trial of an internet‐based versus workbook‐based family intervention study. Journal of Physical Activity & Health 2014;11:348‐58. - PMC - PubMed
Cespedes 2014 {published data only}
    1. Cespedes EM, Horan CM, Gillman MW, Gortmaker SL, Price S, Rifas‐Shiman SL, et al. Participant characteristics and intervention processes associated with reductions in television viewing in the High Five for Kids study. Preventive Medicine: An International Journal Devoted to Practice and Theory 2014;62:64‐70. - PMC - PubMed
Chen 2013 {published data only}
    1. Chen JL, Kwan M, Mac A, Chin NC, Liu K. iStart smart: a primary‐care based and community partnered childhood obesity management program for Chinese‐American children: feasibility study. Journal of Immigrant & Minority Health 2013;15:1125‐8. - PubMed
Chen 2015 {published data only}
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Chen 2016 {published data only}
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Chirita‐Emandi 2014 {published data only}
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Chongviriyaphan 2010 {published data only}
    1. Chongviriyaphan N, Sangthien N, Suthutvoravut U. The nutrition counselling with a behavior modification is effective in obese school‐aged children. Obesity Reviews 2010;11:292‐3.
Cohen 2012 {published data only}
    1. Cohen TR, Hazell T, Vanstone CA, Moore M, Plourde H, Rodd C, et al. Body composition of 6 to 8.5 year old overweight and obese children: 12‐week follow‐up from an eating and exercise behaviour family‐centered lifestyle intervention in Quebec (Canada). FASEB Journal 2012;26:811‐2.
Collins 2010 {published data only}
    1. Collins CE, Morgan PJ, Okely AD, Burrows TL, Cliff DP, Jones RA, et al. HIKCUPS (Hunter Illawarra Kids Challenge Using Parent Support) reduces BMI z‐score up to 2 years: results of a multi‐site randomized trial for overweight children. Obesity Reviews 2010;11:280.
Cooperberg 2014 {published data only}
    1. Cooperberg J. Food for thought: a parental internet‐based intervention to treat childhood obesity in preschool‐aged children. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2014; Vol. 74.
Coppinger 2016 {published data only}
    1. Coppinger T, Lacey S, O'Neill C, Burns C. 'Project Spraoi': a randomized control trial to improve nutrition and physical activity in school children. Contemporary Clinical Trials Communications 2016;3:94‐101. - PMC - PubMed
Cradock 2016 {published data only}
    1. Cradock AL, Barrett JL, Giles CM, Lee RM, Kenney EL, deBlois ME, et al. Promoting physical activity with the Out of School Nutrition and Physical Activity (OSNAP) initiative a cluster‐randomized controlled trial. JAMA Pediatrics 2016;170:155‐62. - PubMed
Crova 2014 {published data only}
    1. Crova C, Struzzolino I, Marchetti R, Masci I, Vannozzi G, Forte R, et al. Cognitively challenging physical activity benefits executive function in overweight children. Journal of Sports Sciences 2014;32:201‐11. - PubMed
Cunningham‐Sabo 2016 {published data only}
    1. Cunningham‐Sabo L, Lohse B, Smith S, Browning R, Strutz E, Nigg C, et al. Fuel for Fun: a cluster‐randomized controlled study of cooking skills, eating behaviors, and physical activity of 4th graders and their families. BMC Public Health 2016;16:444. - PMC - PubMed
Dahiya 2012 {published data only}
    1. Dahiya R, Cowin GJ, Yang Z, Almestehi M, Leong GM. Effect of a 12‐month lifestyle behavioral modification intervention on fat compartmentation in overweight and obese prepubertal children. Endocrine Reviews 2012;33(3 Meeting Abstracts):OR18‐4.
Dai 2006 {published data only}
    1. Dai J, Jiang Z, Zhang B. Exercise and nutrition therapy for simple obesity in children. Chinese Journal of Clinical Rehabilitation 2006;10:20‐2.
Dalton 2013 {published data only}
    1. Dalton WT 3rd, Schetzina KE, McBee MT, Maphis L, Fulton‐Robinson H, Ho AL, et al. Parent report of child's health‐related quality of life after a primary‐care‐based weight management program. Childhood Obesity 2013;9:501‐8. - PMC - PubMed
Daniels 2009a {published data only}
    1. Daniels LA, Magarey A, Battistutta D, Nicholson JM, Farrell A, Davidson G, et al. The NOURISH randomised control trial: positive feeding practices and food preferences in early childhood ‐ a primary prevention program for childhood obesity. BMC Public Health 2009;9:387. - PMC - PubMed
Danielsen 2013 {published data only}
    1. Danielsen YS, Nordhus IH, Juliusson PB, Maehle M, Pallesen S. Effect of a family‐based cognitive behavioural intervention on body mass index, self‐esteem and symptoms of depression in children with obesity (aged 7‐13): a randomised waiting list controlled trial. Obesity Research & Clinical Practice 2013;7:e116‐28. - PubMed
Danielzik 2007 {published data only}
    1. Danielzik S, Pust S, Muller MJ. School‐based interventions to prevent overweight and obesity in prepubertal children: process and 4‐years outcome evaluation of the Kiel Obesity Prevention Study (KOPS). Acta Paediatrica, International Journal of Paediatrics 2007;96:19‐25. - PubMed
da Silva 2015 {published data only}
    1. Silva DF, Bianchini JA, Lopera CA, Capelato DA, Hintze LJ, Nardo CC, et al. Impact of readiness to change behavior on the effects of a multidisciplinary intervention in obese Brazilian children and adolescents. Appetite 2015;87:229‐35. - PubMed
Davis 1999 {published data only}
    1. Davis CE, Hunsberger S, Murray DM, Fabsitz RR, Himes JH, Stephenson LK, et al. Design and statistical analysis for the Pathways study. American Journal of Clinical Nutrition 1999;69:760S‐763S. - PubMed
Davis 2011a {published data only}
    1. Davis AM, Blackburn KS, Dreyer M, Hampl S, Sampilo M. Treatment outcomes across three family‐based behavioral pediatric obesity group treatment programs: Healthy Hawks, Zoom to Health and PHIT kids. Obesity 2011;19:S106.
Davis 2011b {published data only}
    1. Davis CL, Tomporowski PD, McDowell JE, Austin BP, Miller PH, Yanasak NE, et al. Exercise improves executive function and achievement and alters brain activation in overweight children: a randomized, controlled trial. Health Psychology 2011;30:91‐8. - PMC - PubMed
Davis 2014 {published data only}
    1. Davis CL, Pollock NK, Bassali R, Boyle CA, Waller JL, Allison JD, et al. Exercise dose and diabetes risk in overweight and obese children: a randomized control trial. Diabetes Technology and Therapeutics 2014;16:S93. - PMC - PubMed
Davis 2016a {published data only}
    1. Davis AM, Sampilo M, Gallagher KS, Dean K, Saroja MB, Yu Q, et al. Treating rural paediatric obesity through telemedicine vs. telephone: outcomes from a cluster randomized controlled trial. Journal of Telemedicine & Telecare 2016;22(2):86‐95. - PMC - PubMed
Davis 2016b {published data only}
    1. Davis AM, Stough CO, Black WR, Dean K, Sampilo M, Simpson S, et al. Outcomes of a weight management program conjointly addressing parent and child health. Children's Health Care 2016;45:227‐40. - PMC - PubMed
de Mello 2004 {published data only}
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Dennis 2013 {published data only}
    1. Dennis BA, Ergul A, Gower BA, Allison JD, Davis CL. Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program. Childhood Obesity 2013;9:15‐21. - PMC - PubMed
De Ruyter 2013 {published data only}
    1. Ruyter JC, Katan MB, Kuijper LDJ, Liem DG, Olthof MR. The effect of sugar‐free versus sugar‐sweetened beverages on satiety, liking and wanting: an 18 month randomized double‐blind trial in children. PLoS ONE 2013;8:e78039. - PMC - PubMed
DeVault 2009 {published data only}
    1. Vault N, Kennedy T, Hermann J, Mwavita M, Rask P, Jaworsky A. It's all about kids: preventing overweight in elementary school children in Tulsa, OK. Journal of the American Dietetic Association 2009;109:680‐7. - PubMed
Dias 2016 {published data only}
    1. Dias KA, Coombes JS, Green DJ, Gomersall SR, Keating SE, Tjonna AE, et al. Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol. BMJ Open 2016;6:e010929. - PMC - PubMed
Dodds 2014 {published data only}
    1. Dodds P, Wolfenden L, Chapman K, Wellard L, Hughes C, Wiggers J. The effect of energy and traffic light labelling on parent and child fast food selection: a randomised controlled trial. Appetite 2014;73:23‐30. - PubMed
Donnelly 2009 {published data only}
    1. Donnelly JE, Greene JL, Gibson CA, Smith BK, Washburn RA, Sullivan DK, et al. Physical Activity Across the Curriculum (PAAC): a randomized controlled trial to promote physical activity and diminish overweight and obesity in elementary school children. Preventive Medicine 2009;49:336‐41. - PMC - PubMed
Doyle‐Baker 2011 {published data only}
    1. Doyle‐Baker PK, Venner AA, Lyon ME, Fung T. Impact of a combined diet and progressive exercise intervention for overweight and obese children: the B.E. H.I.P. study. Applied Physiology, Nutrition, & Metabolism 2011;36:515‐25. - PubMed
Dreyer 2014 {published data only}
    1. Dreyer Gillette ML, Odar Stough C, Best CM, Beck AR, Hampl SE. Comparison of a condensed 12‐week version and a 24‐week version of a family‐based pediatric weight management program. Childhood obesity 2014;10:375‐82. - PubMed
DuBose 2008 {published data only}
    1. DuBose KD, Mayo MS, Gibson CA, Green JL, Hill JO, Jacobsen DJ, et al. Physical activity across the curriculum (PAAC): rationale and design. Contemporary Clinical Trials 2008;29:83‐93. - PubMed
Duckworth 2009 {published data only}
    1. Duckworth LC, Gately PJ, Radley D, Cooke CB, King RF, Hill AJ. RCT of a high‐protein diet on hunger motivation and weight‐loss in obese children: an extension and replication. Obesity 2009;17:1808‐10. - PubMed
Duncan 2009 {published data only}
    1. Duncan MJ, Al‐Nakeeb Y, Nevill AM. Effects of a 6‐week circuit training intervention on body esteem and body mass index in British primary school children. Body Image 2009;6:216‐20. - PubMed
Dura 2006 {published data only}
    1. Dura Trave T. Treatment of childhood obesity: nutrition education, self‐management and intensive follow‐up. Acta Pediatrica Espanola 2006;64:328‐34.
Economos 2007 {published data only}
    1. Economos CD, Hyatt RR, Goldberg JP, Must A, Naumova EN, Collins JJ, et al. A community intervention reduces BMI z‐score in children: Shape Up Somerville first year results. Obesity 2007;15:1325‐36. - PubMed
El Hage 2012 {published data only}
    1. Hage R, Rocher E, Chappard C, Portier H, Rochefort GY, Benhamou CL. Effect of a 6‐month physical training program on hip structure analysis in obese children. Osteoporosis International 2012;23:S686.
Endevelt 2014 {published data only}
    1. Endevelt R, Elkayam O, Cohen R, Peled R, Tal‐Pony L, Grunwald RM, et al. An intensive family intervention clinic for reducing childhood obesity. Journal of the American Board of Family Medicine: JABFM 2014;27:321‐8. - PubMed
Epstein 1981 {published data only}
    1. Epstein LH, Wing RR, Koeske R, Andrasik F, Ossip DJ. Child and parent weight loss in family‐based behavior modification programs. Journal of Consulting & Clinical Psychology 1981;49:674‐85. - PubMed
Epstein 1984b {published data only}
    1. Epstein LH, Woodall K, Goreczny AJ, Wing RR, Robertson RJ. The modification of activity patterns and energy expenditure in obese young girls. Behavior Therapy 1984;15:101‐8.
Epstein 1986 {published data only}
    1. Epstein LH, Wing RR, Koeske R, Valoski A. Effect of parent weight on weight loss in obese children. Journal of Consulting and Clinical Psychology 1986;54:400‐1. - PubMed
Epstein 1987a {published data only}
    1. Epstein LH, Nudelman S, Wing RR. Long‐term effects of family‐based treatment for obesity on nontreated family members. Behavior Therapy 1987;18:147‐52.
Epstein 1987b {published data only}
    1. Epstein LH, Wing RR, Koeske R, Valoski A. Long‐term effects of family‐based treatment of childhood obesity. Journal of Consulting and Clinical Psychology 1987;55:91‐5. - PubMed
Epstein 1987c {published data only}
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Epstein 1987d {published data only}
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Epstein 1990 {published data only}
    1. Epstein LH, Valoski A, Wing RR, McCurley J. Ten‐year follow‐up of behavioral, family‐based treatment for obese children. JAMA 1990;264:2519‐23. - PubMed
Epstein 1993 {published data only}
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Epstein 1994a {published data only}
    1. Epstein LH, McKenzie SJ, Valoski A, Klein KR, Wing RR. Effects of mastery criteria and contingent reinforcement for family‐based child weight control. Addictive Behaviors 1994;19:135‐45. - PubMed
Epstein 1994b {published data only}
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Epstein 1995 {published data only}
    1. Epstein LH, Valoski AM, Vara LS, McCurley J, Wisniewski L, Kalarchian MA, et al. Effects of decreasing sedentary behavior and increasing activity on weight change in obese children. Health Psychology 1995;14:109‐15. - PubMed
Epstein 2000b {published data only}
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Epstein 2004 {published data only}
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Epstein 2007 {published data only}
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Epstein 2008a {published data only}
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Epstein 2008b {published data only}
    1. Epstein LH, Roemmich JN, Robinson JL, Paluch RA, Winiewicz DD, Fuerch JH, et al. A randomized trial of the effects of reducing television viewing and computer use on body mass index in young children. Archives of Pediatrics & Adolescent Medicine 2008;162:239‐45. - PMC - PubMed
Epstein 2012 {published data only}
    1. Epstein LH, Raja S, Daniel TO, Paluch RA, Wilfley DE, Saelens BE, et al. The built environment moderates effects of family‐based childhood obesity treatment over 2 years. Annals of Behavioral Medicine 2012;44:248‐58. - PMC - PubMed
Erceg 2012 {published data only}
    1. Erceg DNJ. The effects of whole body vibration exercise on metabolic systems in overweight Latino boys. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2012; Vol. 73:274.
Escobedo 2014 {published data only}
    1. Escobedo S, Garca O, Ronquillo D, Caamao M, Rosado J. Supplementation with multiple micronutrients and polyunsaturated fatty acids does not improve school performance of obese children in a rural area of Mexico. FASEB Journal 2014;1:811.23.
Escoto 2008 {published data only}
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Esfarjani 2013 {published data only}
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Estabrooks 2009 {published data only}
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Falbe 2015 {published data only}
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Farpour‐Lambert 2009 {published data only}
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Ferguson 1999a {published data only}
    1. Ferguson MA, Gutin B, Le NA, Karp W, Litaker M, Humphries M, et al. Effects of exercise training and its cessation on components of the insulin resistance syndrome in obese children. International Journal of Obesity & Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 1999;23:889‐95. - PubMed
Ferguson 1999b {published data only}
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Ferrara 2013 {published data only}
    1. Ferrara P, Bufalo F, Ianniello F, Franceschini A, Paolini Paoletti F, Massart F, et al. Diet and physical activity "defeated" Tuberil in treatment of childhood obesity. Minerva Endocrinologica 2013;38:181‐5. - PubMed
Ferrer 1998 {published data only}
    1. Ferrer Gonzalez P, Belda Galiana I, Segarra Aznar FM, Fenollosa Entrena B, Dalmau Serra J. Lipid and anthropometric parameter evolution during the treatment of prepubertal obese patients. Anales Espanoles de Pediatria 1998;48:267‐73. - PubMed
Figueroa‐Colon 1993 {published data only}
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Figueroa‐Colon 1996 {published data only}
    1. Figueroa‐Colon R, Franklin FA, Lee JY, Almen TK, Suskind RM. Feasibility of a clinic‐based hypocaloric dietary intervention implemented in a school setting for obese children. Obesity Research 1996;4:419‐29. - PubMed
Firoozi 2013 {published data only}
    1. Firoozi M, Gheed Rahmat A. Virtual social network for management of obesity in children and adolescents. Iranian Journal of Pediatrics 2013;23:S9‐S10.
Fischer 2014 {published data only}
    1. Fischer M, Svensson V, Danielsson P, Marcus C. Effect of the omega‐3 fatty acids EPA and DHA on physical activity among 8‐year old children, a randomized double blind pilot study. Obesity Reviews 2014;15:245.
Foger 1993 {published data only}
    1. Foger M, Bart G, Rathner G, Jager B, Fischer H, Zollner‐Neussl D. Physical activity, nutritional counseling and psychological guidance in treatment of obese children. A controlled follow‐up study over six months. Monatsschrift Kinderheilkunde. Organ der Deutschen Gesellschaft fur Kinderheilkunde 1993;141:491‐7. - PubMed
Follansbee‐Junger 2010 {published data only}
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Frohna 2008 {published data only}
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Fullerton 2007a {published data only}
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Fullerton 2007b {published data only}
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Furze 2008 {published data only}
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Gajewska 2011 {published data only}
    1. Gajewska J, Weker H, Ambroszkiewicz J, Chelchowska M, Wiech M, Laskowska‐Klita T. Changes in concentration of serum adiponectin multimeric forms following weight reduction programme in prepubertal obese children. Medycyna Wieku Rozwojowego 2011;15:298‐305. - PubMed
Galhardo 2012 {published data only}
    1. Galhardo J, Hunt LP, Lightman SL, Sabin MA, Bergh C, Sodersten P, et al. Normalizing eating behavior reduces body weight and improves gastrointestinal hormonal secretion in obese adolescents. Journal of Clinical Endocrinology & Metabolism 2012;97:E193‐201. - PubMed
Garipagaoglu 2009 {published data only}
    1. Garipagaoglu M, Sahip Y, Darendeliler F, Akdikmen O, Kopuz S, Sut N. Family‐based group treatment versus individual treatment in the management of childhood obesity: randomized, prospective clinical trial. European Journal of Pediatrics 2009;168:1091‐9. - PubMed
Gerards 2012 {published data only}
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Ghatrehsamani 2010 {published data only}
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Goldfield 2000 {published data only}
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Goldfield 2001 {published data only}
    1. Goldfield GS, Epstein LH, Kilanowski CK, Paluch RA, Kogut‐Bossler B. Cost‐effectiveness of group and mixed family‐based treatment for childhood obesity. International Journal of Obesity & Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 2001;25:1843‐9. - PubMed
Goldfield 2006 {published data only}
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Goldfield 2007 {published data only}
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Wang 2013 {published data only}
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Wohlfarth 2013 {published data only}
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    1. Yackobovitch‐Gavan M, Nagelberg N, Phillip M, Ashkenazi‐Hoffnung L, Hershkovitz E, Shalitin S. The influence of diet and/or exercise and parental compliance on health‐related quality of life in obese children. Nutrition Research 2009;29:397‐404. - PubMed
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References to studies awaiting assessment

ACTRN12611000862943 {published data only}
    1. ACTRN12611000862943. Whanau Pakari: a multidisciplinary intervention for child and adolescent obesity. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=343300 (accessed 10th October 2016).
    1. Anderson YC, Wynter LE, Moller KR, Cave TL, Dolan GM, Grant CC, et al. The effect of a multi‐disciplinary obesity intervention compared to usual practice in those ready to make lifestyle changes: design and rationale of Whanau Pakari. BMC obesity 2015;2(41):1. - PMC - PubMed
ISRCTN45032201 {published data only}
    1. Fleming J, Kamal A, Harrison E, Hamborg T, Stewart‐Brown S, Thorogood M, et al. Evaluation of recruitment methods for a trial targeting childhood obesity: Families for Health randomised controlled trial. Trials 2015;16(1):1. - PMC - PubMed
    1. ISRCTN45032201. Trial of ‘Families for Health’: helping families with children who are overweight to manage their weight. www.isrctn.com/ISRCTN45032201 (last accessed 10th October 2016).
    1. Robertson W, Stewart‐Brown S, Stallard N, Petrou S, Griffiths F, Thorogood M, et al. Evaluation of the effectiveness and cost‐effectiveness of Families for Health V2 for the treatment of childhood obesity: study protocol for a randomized controlled trial. Trials 2013;14:81. - PMC - PubMed
ISRCTN97887613 {published data only}
    1. ISRCTN97887613. Exercise looks after you: piloting the programme to prevent obesity in children. www.isrctn.com/ISRCTN97887613 (last accessed 10th October 2016).
JPRN‐UMIN000014896 {published data only}
    1. JPRN‐UMIN000014896. Study on the medical checkup system for prevention of lifestyle diseases including diabetes in underage groups, especially infants, elementary and junior high school children {Study on the Prevention and Treatment of Obesity by Behavioral Approach (Lifestyle modification approach) for Elementary School Children}. upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?recptno=R000017197 (last accessed 10th October 2016).
Jung 1978 {published data only}
    1. Jung K, Maaser R, Ingenillem M, Post C, Woltermann N, Landwehr L, et al. A comprehensive sports program geared to children ‐ illustrated on untrained obese 9‐13 year old children. Medizinische Welt 1978;29:301‐09. - PubMed
NCT00528164 {published data only}
    1. Hare ME, Coday M, Williams NA, Richey PA, Tylavsky FA, Bush AJ. Methods and baseline characteristics of a randomized trial treating early childhood obesity: the Positive Lifestyles for Active Youngsters (Team PLAY) trial. Contemporary Clinical Trials 2012;33(3):534‐49. - PMC - PubMed
    1. NCT00528164. Team PLAY (Positive Lifestyles for Active Youngsters) (Team PLAY). www.clinicaltrials.gov/ct2/show/NCT00528164 (last accessed 10th October 2016).
    1. Williams NA, Coday M, Somes G, Tylavsky FA, Richey PA, Hare M. Risk factors for poor attendance in a family‐based pediatric obesity intervention program for young children. Journal of Developmental & Behavioral Pediatrics 2010;31(9):705‐12. - PMC - PubMed
    1. Williams NA, Fournier J, Coday M, Richey PA, Tylavsky FA, Hare ME. Body esteem, peer difficulties and perceptions of physical health in overweight and obese urban children aged 5 to 7 years. Child: Care, Health and Development 2013;39(6):825‐34. - PMC - PubMed
NCT00723853 {published data only}
    1. NCT00723853. REACH‐OUT: Chicago Children's Diabetes Prevention Program (REACH‐OUT). clinicaltrials.gov/ct2/show/NCT00723853 (last accessed 10th October 2016).
NCT00759746 {published data only}
    1. Best JR, Theim KR, Gredysa DM, Stein RI, Welch RR, Saelens BE, et al. Behavioral economic predictors of overweight children's weight loss. Journal of Consulting and Clinical Psychology 2012;80(6):1086‐96. - PMC - PubMed
    1. NCT00759746. Childhood obesity treatment: a maintenance approach (COMPASS). clinicaltrials.gov/ct2/show/NCT00759746 (last accessed 10th October 2016).
NCT00851201 {published data only}
    1. Khan UI, McGinn AP, Isasi CR, Groisman‐Perelstein A, Diamantis PM, Ginsberg M, et al. Differences in cardiometabolic risk between insulin‐sensitive and insulin‐resistant overweight and obese children. Childhood Obesity 2015;11(3):289‐96. - PMC - PubMed
    1. NCT00851201. Family Weight Management Study. clinicaltrials.gov/ct2/show/NCT00851201 (last accessed 10th October 2016).
NCT01110096 {published data only}
    1. NCT01110096. Family Based Intervention in Childhood obesitY. clinicaltrials.gov/ct2/show/NCT01110096 (last accessed 10th October 2016).
NCT01290016 {published data only}
    1. Cohen TR, Hazell TJ, Vanstone CA, Plourde H, Rodd CJ, Weiler HA. A family‐centered lifestyle intervention to improve body composition and bone mass in overweight and obese children 6 through 8 years: a randomized controlled trial study protocol. BMC Public Health 2013;13:383. - PMC - PubMed
    1. NCT01290016. Youth lifestyle intervention with food and exercise. clinicaltrials.gov/ct2/show/NCT01290016 (last accessed 10th October 2016).
NCT01506245 {published data only}
    1. Farpour‐Lambert N, Maggio A, Martin X, Bucher Della Torre S, Beghetti, M. Effects of family‐based behavioral therapy in group or in individual setting in pre‐pubertal obese children: a randomized controlled trial. Obesity Facts 2012;5:221.
    1. NCT01506245. Exercise and behavioral therapy in obese children. clinicaltrials.gov/ct2/show/NCT01506245 (last accessed 10th October 2016).
NCT01610219 {published data only}
    1. NCT01610219. Lifestyle modification for type 2 diabetes prevention in overweight youth. clinicaltrials.gov/ct2/show/NCT01610219 (last accessed 10th October 2016).
NCT01662570 {published data only}
    1. NCT01662570. Beverage choice and lifestyle modification in overweight youth. clinicaltrials.gov/ct2/show/NCT01662570 (last accessed 10th October 2016).
NCT02724943 {published data only}
    1. Hoelscher DM, Butte NF, Barlow S, Vandewater EA, Sharma SV, Huang T, et al. Incorporating primary and secondary prevention approaches to address childhood obesity prevention and treatment in a low‐income, ethnically diverse population: study design and demographic data from the Texas Childhood Obesity Research Demonstration (TX CORD) study. Childhood Obesity 2015;11(1):71‐91. - PMC - PubMed
    1. NCT02724943. Texas Childhood Obesity Research Demonstration (TX CORD) project. clinicaltrials.gov/ct2/show/NCT02724943 (last accessed 10th October 2016).
    1. Oluyomi AO, Byars A, Byrd‐Williams C, Sharma SV, Durand C, Hoelscher DM, et al. The utility of Geographical Information Systems (GIS) in systems‐oriented obesity intervention projects: the selection of comparable study sites for a quasi‐experimental intervention design‐TX CORD. Childhood Obesity 2015;11(1):58‐70. - PMC - PubMed
NCT02771951 {published data only}
    1. NCT02771951. Clinical/behavioral approach to overweight in Latino youth. clinicaltrials.gov/ct2/show/NCT02771951 (last accessed 10th October 2016).
NCT02779647 {published data only}
    1. NCT02779647. Play as a method to reduce overweight and obesity in children. clinicaltrials.gov/ct2/show/NCT02779647 (last accessed 10th October 2016).
NCT02794090 {published data only}
    1. NCT02794090. Childhood obesity treatment ‐ telephone coaching vc usual care. clinicaltrials.gov/ct2/show/NCT02794090 (last accessed 10th October 2016).
Shapiro 1976 {published data only}
    1. Shapiro Joan R. A comparison of various reward and monitoring procedures in the behavioral treatment of overweight children. Dissertation Abstracts International. 1976; Vol. 36:5816‐7.
Terwilliger 2008 {published data only}
    1. Terwilliger SH. A study of children enrolled in a school‐based physical activity program with attention to overweight and depression [Dissertation]. New York: State University of New York at Binghamton, 2008.

References to ongoing studies

ACTRN12613001037796 {published data only}
    1. ACTRN12613001037796. Effect of exercise intensity on cardiac and vascular function, and intra‐abdominal fat in obese children and adolescents. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=364948 (last accessed 10th October 2016).
    1. Dias KA, Coombes JS, Green DJ, Gomersall SR, Keating SE, Tjonna AE, et al. Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol. BMJ Open 2016;6(4):e010929. - PMC - PubMed
ChiCTR‐IOB‐15005874 {published data only}
    1. ChiCTR‐IOB‐15005874. Effects of weight management program on postural stability and neuromuscular function among obese children. www.chictr.org.cn/showprojen.aspx?proj=10313 (last accessed 10th October 2016).
    1. Sun F, Wang LJ, Wang, L. Effects of weight management program on postural stability and neuromuscular function among obese children: study protocol for a randomized controlled trial. Trials 2015;16:143. - PMC - PubMed
DRKS00007879 {published data only}
    1. DRKS00007879. Development and evaluation of a computer‐based self‐regulation training for obese children and adolescents. drks‐neu.uniklinik‐freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DR... (last accessed 10th October 2016).
ISRCTN81798055 {published data only}
    1. ISRCTN81798055. Child weigHt mANaGement for Ethnically diverse communities study (CHANGE). www.isrctn.com/ISRCTN81798055 (last accessed 10th October 2016).
Moore 2013 {published data only}
    1. Moore SM, Borawski EA, Cuttler L, Ievers‐Landis CE, Love TE. IMPACT: a multi‐level family and school intervention targeting obesity in urban youth. Contemporary Clinical Trials 2013;36(2):574‐86. - PMC - PubMed
NCT01221220 {published data only}
    1. NCT01221220. Environmental strategies & behavior change to reduce overeating in obese children. clinicaltrials.gov/ct2/show/NCT01221220 (last accessed 10th October 2016).
NCT01574352 {published data only}
    1. Larsen KT, Huang T, Moller NC, Andersen LB, Ried‐Larsen M. Effectiveness of a one‐year multi‐component day‐camp intervention for overweight children: study protocol of the Odense overweight intervention study (OOIS). BMC Public Health 2014;14:313. - PMC - PubMed
    1. NCT01574352. The Odense Overweight Intervention Study (OOIS). clinicaltrials.gov/ct2/show/NCT01574352 (last accessed 10th October 2016).
NCT01642836 {published data only}
    1. NCT01642836. Clinic, family & community collaboration to treat overweight and obese children (Stanford GOALS). clinicaltrials.gov/ct2/show/NCT01642836 (last accessed 10th October 2016).
    1. Robinson TN, Matheson D, Desai M, Wilson DM, Weintraub DL, Haskell WL, et al. Family, community and clinic collaboration to treat overweight and obese children: Stanford GOALS ‐ a randomized controlled trial of a three‐year, multi‐component, multi‐level, multi‐setting intervention. Contemporary Clinical Trials 2013;36(2):421‐35. - PMC - PubMed
NCT01736748 {published data only}
    1. NCT01736748. Dynamo: a tailored lifestyle promotion intervention among pediatric patients with cardiometabolic risk factors. clinicaltrials.gov/ct2/show/NCT01736748 (last accessed 10th October 2016).
NCT02082080 {published data only}
    1. NCT02082080. Prevention and control of obesity in primary school children in Tehran. clinicaltrials.gov/ct2/show/NCT02082080 (last accessed 10th October 2016).
NCT02124460 {published data only}
    1. NCT02124460. Connect 4 Health: an intervention to improve childhood obesity outcomes. clinicaltrials.gov/ct2/show/NCT02124460 (last accessed 10th October 2016).
    1. Taveras EM, Marshall R, Sharifi M, Avalon E, Fiechtner L, Horan C, et al. Connect for Health: design of a clinical‐community childhood obesity intervention testing best practices of positive outliers. Contemporary Clinical Trials 2015;45(Pt B):287‐95. - PMC - PubMed
NCT02258126 {published data only}
    1. NCT02258126. Effect of exercise on hepatic fat in overweight children. clinicaltrials.gov/ct2/show/NCT02258126 (last accessed 10th October 2016).
NCT02343367 {published data only}
    1. NCT02343367. Health4Kids intervention trial for Hispanic families. clinicaltrials.gov/ct2/show/NCT02343367 (last accessed 10th October 2016).
NCT02560493 {published data only}
    1. NCT02560493. Gaming technology to encourage healthy weight and activity in youth. clinicaltrials.gov/ct2/show/NCT02560493 (last accessed 10th October 2016).
NCT02573142 {published data only}
    1. NCT02573142. Integrated child obesity treatment study: Bull City healthy and fit. clinicaltrials.gov/ct2/show/NCT02573142 (last accessed 10th October 2016).
NCT02684214 {published data only}
    1. NCT02684214. Implementing prevention plus for childhood overweight and obesity in food secure and insecure families. clinicaltrials.gov/ct2/show/NCT02684214 (last accessed 10th October 2016).
NCT02711488 {published data only}
    1. NCT02711488. Managing adolescent obesity at local level by combining primary and secondary intervention. clinicaltrials.gov/ct2/show/NCT02711488 (last accessed 10th October 2016).
NCT02720302 {published data only}
    1. NCT02720302. Treatment of overweight in children on distance. clinicaltrials.gov/ct2/show/NCT02720302 (last accessed 10th October 2016).
NCT02773823 {published data only}
    1. NCT02773823. A behavior intervention study on cardiovascular health among Chinese obese schoolchildren. clinicaltrials.gov/ct2/show/NCT02773823 (last accessed 10th October 2016).
RBR‐8ttw64 {published data only}
    1. RBR‐8ttw64. Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial. www.ensaiosclinicos.gov.br/rg/RBR‐8ttw64/ (last accessed 10th October 2016).

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