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Review
. 2017 Jul 20;35(21):2450-2456.
doi: 10.1200/JCO.2017.72.8089. Epub 2017 Jun 22.

Immunotherapy for Brain Tumors

John H Sampson  1 , Marcela V Maus  1 , Carl H June  1
Affiliations
Review

Immunotherapy for Brain Tumors

John H Sampson et al. J Clin Oncol. .

Abstract

Glioblastoma (GBM) is the most lethal form of brain tumor and remains a large, unmet medical need. This review focuses on recent advances in the neurosciences that converge with the broader field of immuno-oncology. Recent findings in neuroanatomy provide a basis for new approaches of cellular therapies for tumors that involve the CNS. The ultimate success of immunotherapy in the CNS will require improved imaging technologies and methods for analysis of the tumor microenvironment in patients with GBM. It is likely that combinatorial approaches with targeted immunotherapies will be required to exploit the vulnerabilities of GBM and other brain tumors.

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