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Comment
. 2017 Jun 8:8:396.
doi: 10.3389/fphys.2017.00396. eCollection 2017.

Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state

Ove Eriksson  1 , Maciej Lalowski  1 , Dan Lindholm  1   2
Affiliations
Comment

Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state

Ove Eriksson et al. Front Physiol. .
No abstract available

Keywords: LACTB; cell proliferation; human cancer; lipid metabolism; mitochondria; phospholipids.

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Figures

Figure 1
Figure 1
Hypothetical model of PS decarboxylase activity regulated by the spatial arrangement of the outer and inner mitochondrial membranes. Conversion of substrate PS (red) into PE in the outer mitochondrial membrane (MOM) is carried out by PISD1 protruding from the inner mitochondrial membrane (MIM). For PS decarboxylase to convert PS to PE, the MOM and MIM need to be in close apposition determined by the mitochondrial contact sites and the cristae organizing system (MICOS). LACTB may influence the degree of membrane apposition and hence the rate of PE formation.
See this image and copyright information in PMC

Comment on

  • LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
    Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA. Keckesova Z, et al. Nature. 2017 Mar 30;543(7647):681-686. doi: 10.1038/nature21408. Epub 2017 Mar 22. Nature. 2017. PMID: 28329758 Free PMC article.

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