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. 2016 Sep 15;2(4):FS136.
doi: 10.4155/fsoa-2016-0019. eCollection 2016 Dec.

The effect of concentrated growth factors in the treatment of periodontal intrabony defects

Jing Qiao  1 , Jinyu Duan  1 , Yong Zhang  1 , Yi Chu  1 , Changzhou Sun  1
Affiliations

The effect of concentrated growth factors in the treatment of periodontal intrabony defects

Jing Qiao et al. Future Sci OA. .

Abstract

Aim: To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.

Methods: Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.

Results: No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).

Conclusion: Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.

Keywords: bovine porous bone mineral; concentrated growth factors; periodontal intrabony defects; periodontal regeneration.

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Conflict of interest statement

Financial & competing interests disclosure J Qiao accepted the support by Ministry of Science and Technology of China under contract International Science & Technology Cooperation Program foundation Nr.1019. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Concentrated growth factors.
(A) Three blood fractions were obtained through centrifuge process (1) a superior phase represented by the serum; (2) an interim phase represented by a very large and dense polymerized fibrin block containing the CGFs, white blood cells and stem cells; and (3) the lower red blood cell layer. (B) CGFs separated from platelet-poor plasma.
<b>Figure 2.</b>
Figure 2.
(A) An example in the experimental group: the second right mandibular premolar, baseline. (B) Intra-surgical findings. (C) Mixture of CGFs and BPBM granules was placed into the defect. (D) CGFs membrane was placed. (E) Flap sutured. (F) 1 year post-surgery.
<b>Figure 3.</b>
Figure 3.. Radiographic landmarks.
AC: Alveolar crest; BD: Base of the defect; CEJ: Cemento–enamel junction.
<b>Figure 4.</b>
Figure 4.. Periapical radiograph of the second right mandibular premolar 1 year post-surgery.
See this image and copyright information in PMC

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