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Review
. 2017 Jun 23;6(3):28.
doi: 10.3390/pathogens6030028.

Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency

Nikki M Thellman  1 , Steven J Triezenberg  2
Affiliations
Review

Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency

Nikki M Thellman et al. Pathogens. .

Abstract

All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent infection provide valuable insight on the host processes regulating viral establishment and maintenance of latency. More robust and rapid than infections in live animal studies, advancements in neuronal culture techniques have made the systematic analysis of viral reactivation mechanisms feasible. Only recently have human neuronal cell lines been available, but models in the natural host cell are a critical addition to the currently available models.

Keywords: HSV-1; HSV-2; cell culture; latent infection; lytic infection; neuron; quiescent infection.

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Conflict of interest statement

The authors declare no conflict of interest.

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