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Comment
. 2017 Sep;24(9):1471-1472.
doi: 10.1038/cdd.2017.45. Epub 2017 Jun 23.

Gut check: dead cell samples leads to tolerant examples

Thomas H Oguin 3rd  1 , Jennifer Martinez  1
Affiliations
Comment

Gut check: dead cell samples leads to tolerant examples

Thomas H Oguin 3rd et al. Cell Death Differ. 2017 Sep.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Efferocytosis induces cell type-specific programming. In Cummings et al., the authors use the novel VDTR mouse to demonstrate that uptake of apoptotic IECs triggers a differential transcriptional response in a cell specific manner. Two macrophage subsets (CD103+ and CD103+ CD11b+ macrophages) phagocytose IECs and upregulate transcriptional programs associated with dead cell clearance, immunosuppression, lipid metabolism, branch-chain amino acid (AA) catabolism. CD103+ dendritic cells (DC), on the other hand, promote immunosuppression and upregulate molecules critical for the recruitment, differentiation, and activity of regulatory T cells (Treg)
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References

    1. Arandjelovic S et al. Nat Immunol 2015; 16: 907–917. - PMC - PubMed
    1. Green DR. Immunity 2011; 35: 441–444. - PubMed
    1. Nagata S. Ann N Y Acad Sci 2010; 1209: 10–16. - PubMed
    1. Cummings RJ et al. Nature 2016; 539: 565–569. - PMC - PubMed
    1. Poon IK et al. Nat Rev Immunol 2014; 14: 166–180. - PMC - PubMed

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