Excretory/secretory products of anisakid nematodes: biological and pathological roles

doi:10.1186/s13028-017-0310-3

Review

. 2017 Jun 23;59(1):42.

doi: 10.1186/s13028-017-0310-3.

Excretory/secretory products of anisakid nematodes: biological and pathological roles

Foojan Mehrdana¹, Kurt Buchmann²

Affiliations

¹ Laboratory of Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark. foojan@sund.ku.dk.
² Laboratory of Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark.

PMID: 28645306
PMCID: PMC5482935
DOI: 10.1186/s13028-017-0310-3

Review

Excretory/secretory products of anisakid nematodes: biological and pathological roles

Foojan Mehrdana et al. Acta Vet Scand. 2017.

. 2017 Jun 23;59(1):42.

doi: 10.1186/s13028-017-0310-3.

Authors

Foojan Mehrdana¹, Kurt Buchmann²

Affiliations

¹ Laboratory of Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark. foojan@sund.ku.dk.
² Laboratory of Aquatic Pathobiology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark.

PMID: 28645306
PMCID: PMC5482935
DOI: 10.1186/s13028-017-0310-3

Abstract

Parasites from the family Anisakidae are widely distributed in marine fish populations worldwide and mainly nematodes of the three genera Anisakis, Pseudoterranova and Contracaecum have attracted attention due to their pathogenicity in humans. Their life cycles include invertebrates and fish as intermediate or transport hosts and mammals or birds as final hosts. Human consumption of raw or underprocessed seafood containing third stage larvae of anisakid parasites may elicit a gastrointestinal disease (anisakidosis) and allergic responses. Excretory and secretory (ES) compounds produced by the parasites are assumed to be key players in clinical manifestation of the disease in humans, but the molecules are likely to play a general biological role in invertebrates and lower vertebrates as well. ES products have several functions during infection, e.g. penetration of host tissues and evasion of host immune responses, but are at the same time known to elicit immune responses (including antibody production) both in fish and mammals. ES proteins from anisakid nematodes, in particular Anisakis simplex, are currently applied for diagnostic purposes but recent evidence suggests that they also may have a therapeutic potential in immune-related diseases.

Keywords: Allergy; Anisakidosis; Anisakids; Excretory/secretory products.

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1. Paggi L, Mattiucci S, Gibson DI, Berland B, Nascetti G, Cianchi R, Bullini L. Pseudoterranova decipiens species A and B (Nematoda, Ascaridoidea): nomenclatural designation, morphological diagnostic characters and genetic markers. Syst Parasitol. 2000;45:185–197. doi: 10.1023/A:1006296316222. - DOI - PubMed

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[1] Orecchia P, Mattiucci S, D’Amelio S, Paggi L, Plötz J, Cianchi R, Nascetti G, Arduino P, Bullini L. Two new members in the Contracaecum osculatum complex (Nematoda, Ascaridoidea) from the Antarctic. Int J Parasitol. 1994;24:367–377. doi: 10.1016/0020-7519(94)90084-1. - DOI - PubMed

[2] Orecchia P, Mattiucci S, D’Amelio S, Paggi L, Plötz J, Cianchi R, Nascetti G, Arduino P, Bullini L. Two new members in the Contracaecum osculatum complex (Nematoda, Ascaridoidea) from the Antarctic. Int J Parasitol. 1994;24:367–377. doi: 10.1016/0020-7519(94)90084-1. - DOI - PubMed

[3] Mattiucci S, Nascetti G, Clanchi R, Paggi L, Arduino P, Margolis L, Brattey J, Webb S, D’Amelio S, Orecchia P, Bullini L. Genetic and ecological data on the Anisakis simplex complex, with evidence for a new species (Nematoda, Ascaridoidea, Anisakidae) J Parasitol. 1997;83:401–416. doi: 10.2307/3284402. - DOI - PubMed

[4] Mattiucci S, Nascetti G, Clanchi R, Paggi L, Arduino P, Margolis L, Brattey J, Webb S, D’Amelio S, Orecchia P, Bullini L. Genetic and ecological data on the Anisakis simplex complex, with evidence for a new species (Nematoda, Ascaridoidea, Anisakidae) J Parasitol. 1997;83:401–416. doi: 10.2307/3284402. - DOI - PubMed

[5] Mattiucci S, Cipriani P, Webb SC, Paoletti M, Marcer F, Bellisario B, Gibson DI, Nascetti G. Genetic and morphological approaches distinguish the three sibling species of the Anisakis simplex species complex, with a species designation as Anisakis berlandi n. sp. for A. simplex sp. C (Nematoda: Anisakidae) J Parasitol. 2014;100:199–214. doi: 10.1645/12-120.1. - DOI - PubMed

[6] Mattiucci S, Cipriani P, Webb SC, Paoletti M, Marcer F, Bellisario B, Gibson DI, Nascetti G. Genetic and morphological approaches distinguish the three sibling species of the Anisakis simplex species complex, with a species designation as Anisakis berlandi n. sp. for A. simplex sp. C (Nematoda: Anisakidae) J Parasitol. 2014;100:199–214. doi: 10.1645/12-120.1. - DOI - PubMed

[7] Mattiucci S, Paggi L, Nascetti G, Ishikura H, Kikuchi K, Sato N, Cianchi R, Bullini L. Allozyme and morphological identification of Anisakis, Contracaecum and Pseudoterranova from Japanese waters (Nematoda, Ascaridoidea) Syst Parasitol. 1998;40:81–92. doi: 10.1023/A:1005914926720. - DOI

[8] Mattiucci S, Paggi L, Nascetti G, Ishikura H, Kikuchi K, Sato N, Cianchi R, Bullini L. Allozyme and morphological identification of Anisakis, Contracaecum and Pseudoterranova from Japanese waters (Nematoda, Ascaridoidea) Syst Parasitol. 1998;40:81–92. doi: 10.1023/A:1005914926720. - DOI

[9] Paggi L, Mattiucci S, Gibson DI, Berland B, Nascetti G, Cianchi R, Bullini L. Pseudoterranova decipiens species A and B (Nematoda, Ascaridoidea): nomenclatural designation, morphological diagnostic characters and genetic markers. Syst Parasitol. 2000;45:185–197. doi: 10.1023/A:1006296316222. - DOI - PubMed

[10] Paggi L, Mattiucci S, Gibson DI, Berland B, Nascetti G, Cianchi R, Bullini L. Pseudoterranova decipiens species A and B (Nematoda, Ascaridoidea): nomenclatural designation, morphological diagnostic characters and genetic markers. Syst Parasitol. 2000;45:185–197. doi: 10.1023/A:1006296316222. - DOI - PubMed

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Excretory/secretory products of anisakid nematodes: biological and pathological roles

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Excretory/secretory products of anisakid nematodes: biological and pathological roles

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